ENSG00000073792


Homo sapiens

Features
Gene ID: ENSG00000073792
  
Biological name :IGF2BP2
  
Synonyms : IGF2BP2 / insulin like growth factor 2 mRNA binding protein 2 / Q9Y6M1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q27.2
Gene start: 185643739
Gene end: 185825056
  
Corresponding Affymetrix probe sets: 218847_at (Human Genome U133 Plus 2.0 Array)   223963_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000320204
Ensembl peptide - ENSP00000371634
Ensembl peptide - ENSP00000410242
Ensembl peptide - ENSP00000413787
NCBI entrez gene - 10644     See in Manteia.
OMIM - 608289
RefSeq - NM_001291875
RefSeq - NM_006548
RefSeq - XM_017005562
RefSeq - NM_001007225
RefSeq - NM_001291869
RefSeq - NM_001291872
RefSeq - NM_001291873
RefSeq - NM_001291874
RefSeq - XM_006713477
RefSeq - XM_017005557
RefSeq - XM_017005558
RefSeq - XM_017005559
RefSeq - XM_017005560
RefSeq - XM_017005561
RefSeq Peptide - NP_001278804
RefSeq Peptide - NP_001278803
RefSeq Peptide - NP_006539
RefSeq Peptide - NP_001007226
RefSeq Peptide - NP_001278798
RefSeq Peptide - NP_001278801
RefSeq Peptide - NP_001278802
swissprot - Q9Y6M1
swissprot - F8W930
Ensembl - ENSG00000073792
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, noninsulin-dependent, susceptibility to}, 125853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf2bp2aENSDARG00000003421Danio rerio
 igf2bp2bENSDARG00000099758Danio rerio
 IGF2BP2ENSGALG00000033195Gallus gallus
 Q5SF07ENSMUSG00000033581Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NZI8 / IGF2BP1 / insulin like growth factor 2 mRNA binding protein 1ENSG0000015921764
O00425 / IGF2BP3 / insulin like growth factor 2 mRNA binding protein 3ENSG0000013623162


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR028743  Insulin-like growth factor 2 mRNA-binding protein 2
 IPR034843  IGF2BP2, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0017148 negative regulation of translation ISS
 biological_processGO:0042035 regulation of cytokine biosynthetic process IC
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045182 translation regulator activity ISS
 molecular_functionGO:0048027 mRNA 5"-UTR binding IDA


Pathways (from Reactome)
Pathway description
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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