ENSG00000159217


Homo sapiens

Features
Gene ID: ENSG00000159217
  
Biological name :IGF2BP1
  
Synonyms : IGF2BP1 / insulin like growth factor 2 mRNA binding protein 1 / Q9NZI8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.32
Gene start: 48997412
Gene end: 49055650
  
Corresponding Affymetrix probe sets: 223689_at (Human Genome U133 Plus 2.0 Array)   227377_at (Human Genome U133 Plus 2.0 Array)   241574_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000290341
Ensembl peptide - ENSP00000389135
NCBI entrez gene - 10642     See in Manteia.
OMIM - 608288
RefSeq - XM_017024022
RefSeq - NM_001160423
RefSeq - NM_006546
RefSeq - XM_005256955
RefSeq - XM_011524201
RefSeq Peptide - NP_001153895
RefSeq Peptide - NP_006537
swissprot - Q9NZI8
Ensembl - ENSG00000159217
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 igf2bp1ENSDARG00000061478Danio rerio
 O42254ENSGALG00000041204Gallus gallus
 O88477ENSMUSG00000013415Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00425 / IGF2BP3 / insulin like growth factor 2 mRNA binding protein 3ENSG0000013623174
Q9Y6M1 / IGF2BP2 / insulin like growth factor 2 mRNA binding protein 2ENSG0000007379267


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR034837  IGF2BP1, RNA recognition motif 1
 IPR034842  IGF2BP1, RNA recognition motif 2
 IPR035979  RNA-binding domain superfamily
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006403 RNA localization IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0010610 regulation of mRNA stability involved in response to stress IMP
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0022013 pallium cell proliferation in forebrain IEA
 biological_processGO:0042035 regulation of cytokine biosynthetic process IC
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0070934 CRD-mediated mRNA stabilization IDA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070937 CRD-mediated mRNA stability complex IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045182 translation regulator activity IDA
 molecular_functionGO:0048027 mRNA 5"-UTR binding IDA


Pathways (from Reactome)
Pathway description
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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