ENSG00000074416


Homo sapiens

Features
Gene ID: ENSG00000074416
  
Biological name :MGLL
  
Synonyms : MGLL / monoglyceride lipase / Q99685
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q21.3
Gene start: 127689062
Gene end: 127823250
  
Corresponding Affymetrix probe sets: 211026_s_at (Human Genome U133 Plus 2.0 Array)   225102_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417060
Ensembl peptide - ENSP00000404146
Ensembl peptide - ENSP00000417489
Ensembl peptide - ENSP00000420125
Ensembl peptide - ENSP00000419340
Ensembl peptide - ENSP00000417689
Ensembl peptide - ENSP00000265052
Ensembl peptide - ENSP00000381173
Ensembl peptide - ENSP00000381176
Ensembl peptide - ENSP00000402798
NCBI entrez gene - 11343     See in Manteia.
OMIM - 609699
RefSeq - XM_017005666
RefSeq - NM_001256585
RefSeq - NM_007283
RefSeq - XM_011512377
RefSeq - XM_011512378
RefSeq - XM_011512379
RefSeq - XM_011512382
RefSeq - XM_011512383
RefSeq - XM_017005662
RefSeq - XM_017005663
RefSeq - XM_017005664
RefSeq - XM_017005665
RefSeq - NM_001003794
RefSeq Peptide - NP_009214
RefSeq Peptide - NP_001003794
RefSeq Peptide - NP_001243514
swissprot - H7C4E0
swissprot - H7C599
swissprot - E7EWX8
swissprot - Q99685
swissprot - A0A0C4DFN3
swissprot - H7C5K5
swissprot - C9JAM4
swissprot - C9J8Q3
Ensembl - ENSG00000074416
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgllENSDARG00000036820Danio rerio
 MGLLENSGALG00000032736Gallus gallus
 MgllENSMUSG00000033174Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000073  Alpha/beta hydrolase fold-1
 IPR022742  Serine aminopeptidase, S33
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0009966 regulation of signal transduction IBA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process ISS
 biological_processGO:0019433 triglyceride catabolic process IEA
 biological_processGO:0036155 acylglycerol acyl-chain remodeling TAS
 biological_processGO:0046464 acylglycerol catabolic process ISS
 biological_processGO:0050727 regulation of inflammatory response ISS
 biological_processGO:0051930 regulation of sensory perception of pain ISS
 biological_processGO:2000124 regulation of endocannabinoid signaling pathway ISS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0019898 extrinsic component of membrane ISS
 molecular_functionGO:0004622 lysophospholipase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0047372 acylglycerol lipase activity TAS
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of DAG and TAG
Triglyceride catabolism
Arachidonate production from DAG


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000074416 MGLL / Q99685 / monoglyceride lipase  / complex






 

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