ENSMUSG00000033174


Mus musculus

Features
Gene ID: ENSMUSG00000033174
  
Biological name :Mgll
  
Synonyms : Mgll / Monoglyceride lipase / O35678
  
Possible biological names infered from orthology : Q99685
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 88724412
Gene end: 88828360
  
Corresponding Affymetrix probe sets: 10539894 (MoGene1.0st)   1426785_s_at (Mouse Genome 430 2.0 Array)   1431331_at (Mouse Genome 430 2.0 Array)   1442560_at (Mouse Genome 430 2.0 Array)   1450391_a_at (Mouse Genome 430 2.0 Array)   1453836_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127374
Ensembl peptide - ENSMUSP00000144883
Ensembl peptide - ENSMUSP00000145364
Ensembl peptide - ENSMUSP00000145068
Ensembl peptide - ENSMUSP00000086872
Ensembl peptide - ENSMUSP00000109211
Ensembl peptide - ENSMUSP00000109212
Ensembl peptide - ENSMUSP00000109215
NCBI entrez gene - 23945     See in Manteia.
MGI - MGI:1346042
RefSeq - NM_001166251
RefSeq - XM_011241332
RefSeq - NM_011844
RefSeq - NM_001166249
RefSeq - NM_001166250
RefSeq Peptide - NP_001159721
RefSeq Peptide - NP_001159722
RefSeq Peptide - NP_001159723
RefSeq Peptide - NP_035974
swissprot - Q3UFN1
swissprot - D3YYS6
swissprot - A0A0N4SUZ2
swissprot - E9Q3B9
swissprot - O35678
Ensembl - ENSMUSG00000033174
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgllENSDARG00000036820Danio rerio
 MGLLENSGALG00000032736Gallus gallus
 MGLLENSG00000074416Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000073  Alpha/beta hydrolase fold-1
 IPR022742  Serine aminopeptidase, S33
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0009966 regulation of signal transduction IMP
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019369 arachidonic acid metabolic process IMP
 biological_processGO:0019433 triglyceride catabolic process IEA
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0046464 acylglycerol catabolic process IMP
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0051930 regulation of sensory perception of pain IMP
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:2000124 regulation of endocannabinoid signaling pathway IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043196 varicosity IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0047372 acylglycerol lipase activity IMP
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of DAG and TAG
Arachidonate production from DAG


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005533 increased body temperature "greater than the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0008032 abnormal lipolysis "anomaly in the process of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv2tm1Dlim/Etv2tm2.1Dlim,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033174 Mgll / O35678 / Monoglyceride lipase / Q99685*  / complex






 

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