ENSG00000077348


Homo sapiens

Features
Gene ID: ENSG00000077348
  
Biological name :EXOSC5
  
Synonyms : EXOSC5 / exosome component 5 / Q9NQT4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 41386374
Gene end: 41397479
  
Corresponding Affymetrix probe sets: 218481_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000221233
Ensembl peptide - ENSP00000471557
Ensembl peptide - ENSP00000472396
Ensembl peptide - ENSP00000471002
NCBI entrez gene - 56915     See in Manteia.
OMIM - 606492
RefSeq - NM_020158
RefSeq Peptide - NP_064543
swissprot - Q9NQT4
swissprot - M0R050
swissprot - M0R102
swissprot - M0R289
Ensembl - ENSG00000077348
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc5ENSDARG00000040557Danio rerio
 Exosc5ENSMUSG00000061286Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006401 RNA catabolic process IEA
 biological_processGO:0016075 rRNA catabolic process IBA
 biological_processGO:0031125 rRNA 3"-end processing IBA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IMP
 biological_processGO:0045006 DNA deamination IDA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071051 polyadenylation-dependent snoRNA 3"-end processing IBA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0035327 transcriptionally active chromatin IMP
 molecular_functionGO:0000175 3"-5"-exoribonuclease activity NAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
ATF4 activates genes
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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