ENSMUSG00000061286


Mus musculus

Features
Gene ID: ENSMUSG00000061286
  
Biological name :Exosc5
  
Synonyms : Exosc5 / Exosome complex component RRP46 / Q9CRA8
  
Possible biological names infered from orthology : exosome component 5 / Q9NQT4
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 25659164
Gene end: 25671368
  
Corresponding Affymetrix probe sets: 10551173 (MoGene1.0st)   1417167_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145921
Ensembl peptide - ENSMUSP00000146157
Ensembl peptide - ENSMUSP00000145948
Ensembl peptide - ENSMUSP00000078580
NCBI entrez gene - 27998     See in Manteia.
MGI - MGI:107889
RefSeq - NM_138586
RefSeq Peptide - NP_613052
swissprot - A0A0U1RPX0
swissprot - A0A0U1RPC2
swissprot - Q9CRA8
Ensembl - ENSMUSG00000061286
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc5ENSDARG00000040557Danio rerio
 EXOSC5ENSG00000077348Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001247  Exoribonuclease, phosphorolytic domain 1
 IPR015847  Exoribonuclease, phosphorolytic domain 2
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027408  PNPase/RNase PH domain superfamily
 IPR036345  Exoribonuclease, PH domain 2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0006401 RNA catabolic process IMP
 biological_processGO:0016075 rRNA catabolic process IBA
 biological_processGO:0031125 rRNA 3"-end processing IBA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IEA
 biological_processGO:0045006 DNA deamination IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071028 nuclear mRNA surveillance IBA
 biological_processGO:0071051 polyadenylation-dependent snoRNA 3"-end processing IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0035327 transcriptionally active chromatin IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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