ENSG00000078140


Homo sapiens

Features
Gene ID: ENSG00000078140
  
Biological name :UBE2K
  
Synonyms : P61086 / UBE2K / ubiquitin conjugating enzyme E2 K
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p14
Gene start: 39698044
Gene end: 39782792
  
Corresponding Affymetrix probe sets: 202346_at (Human Genome U133 Plus 2.0 Array)   202347_s_at (Human Genome U133 Plus 2.0 Array)   225179_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425301
Ensembl peptide - ENSP00000390483
Ensembl peptide - ENSP00000421203
Ensembl peptide - ENSP00000421422
Ensembl peptide - ENSP00000261427
NCBI entrez gene - 3093     See in Manteia.
OMIM - 602846
RefSeq - NM_001312646
RefSeq - NM_001111112
RefSeq - NM_001111113
RefSeq - NM_001312647
RefSeq - NM_001312648
RefSeq - NM_005339
RefSeq Peptide - NP_005330
RefSeq Peptide - NP_001299575
RefSeq Peptide - NP_001299576
RefSeq Peptide - NP_001299577
RefSeq Peptide - NP_001104582
RefSeq Peptide - NP_001104583
swissprot - P61086
swissprot - D6RFX1
swissprot - D6RDM7
Ensembl - ENSG00000078140
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2kaENSDARG00000089055Danio rerio
 ube2kbENSDARG00000013505Danio rerio
 UBE2KENSGALG00000014290Gallus gallus
 Ube2kENSMUSG00000029203Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0010994 free ubiquitin chain polymerization IDA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035458 cellular response to interferon-beta IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IDA


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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