ENSMUSG00000029203


Mus musculus

Features
Gene ID: ENSMUSG00000029203
  
Biological name :Ube2k
  
Synonyms : P61087 / Ube2k / ubiquitin-conjugating enzyme E2K
  
Possible biological names infered from orthology : P61086
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 65537233
Gene end: 65598988
  
Corresponding Affymetrix probe sets: 10522149 (MoGene1.0st)   1417186_at (Mouse Genome 430 2.0 Array)   1417187_at (Mouse Genome 430 2.0 Array)   1417188_s_at (Mouse Genome 430 2.0 Array)   1443148_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144308
Ensembl peptide - ENSMUSP00000144619
Ensembl peptide - ENSMUSP00000144580
Ensembl peptide - ENSMUSP00000144428
Ensembl peptide - ENSMUSP00000144366
Ensembl peptide - ENSMUSP00000122471
Ensembl peptide - ENSMUSP00000143941
Ensembl peptide - ENSMUSP00000144060
Ensembl peptide - ENSMUSP00000144192
NCBI entrez gene - 53323     See in Manteia.
MGI - MGI:1858216
RefSeq - XM_017320985
RefSeq - NM_001310618
RefSeq - NM_001310619
RefSeq - NM_016786
RefSeq Peptide - NP_001297548
RefSeq Peptide - NP_058066
RefSeq Peptide - NP_001297547
swissprot - D3Z4U3
swissprot - P61087
swissprot - A0A0J9YUI1
swissprot - A0A0J9YU07
swissprot - A0A0J9YUR9
swissprot - F8WIC2
swissprot - Q3V3R8
swissprot - Q6ZWQ6
Ensembl - ENSMUSG00000029203
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2kaENSDARG00000089055Danio rerio
 ube2kbENSDARG00000013505Danio rerio
 UBE2KENSGALG00000014290Gallus gallus
 UBE2KENSG00000078140Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR009060  UBA-like superfamily
 IPR015940  Ubiquitin-associated domain
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010994 free ubiquitin chain polymerization IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032433 filopodium tip IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Chn1Gt714Lex/Chn1Gt714Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Ube2kGt(XK109)Byg/Ube2k+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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