ENSG00000078618


Homo sapiens

Features
Gene ID: ENSG00000078618
  
Biological name :NRDC
  
Synonyms : nardilysin convertase / NRDC / O43847
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p32.3
Gene start: 51789191
Gene end: 51878937
  
Corresponding Affymetrix probe sets: 208709_s_at (Human Genome U133 Plus 2.0 Array)   229422_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262679
Ensembl peptide - ENSP00000398464
Ensembl peptide - ENSP00000442262
Ensembl peptide - ENSP00000444416
Ensembl peptide - ENSP00000346890
NCBI entrez gene - 4898     See in Manteia.
OMIM - 602651
RefSeq - XM_017001375
RefSeq - NM_001101662
RefSeq - NM_001242361
RefSeq - NM_002525
RefSeq - XM_005270903
RefSeq - XM_011541522
RefSeq - XM_011541523
RefSeq - XM_011541525
RefSeq Peptide - NP_001095132
RefSeq Peptide - NP_002516
RefSeq Peptide - NP_001229290
swissprot - H0Y5G9
swissprot - B1AKJ5
swissprot - O43847
swissprot - F5H7V1
swissprot - G3V1R5
Ensembl - ENSG00000078618
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrd1aENSDARG00000019596Danio rerio
 nrd1bENSDARG00000062372Danio rerio
 NRDCENSGALG00000010565Gallus gallus
 Nrd1ENSMUSG00000053510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IDE / P14735 / insulin degrading enzymeENSG0000011991227


Protein motifs (from Interpro)
Interpro ID Name
 IPR001431  Peptidase M16, zinc-binding site
 IPR007863  Peptidase M16, C-terminal
 IPR011249  Metalloenzyme, LuxS/M16 peptidase-like
 IPR011765  Peptidase M16, N-terminal
 IPR032632  Peptidase M16, middle/third domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007528 neuromuscular junction development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0052548 regulation of endopeptidase activity IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009986 cell surface TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048408 epidermal growth factor binding TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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