ENSG00000119912


Homo sapiens

Features
Gene ID: ENSG00000119912
  
Biological name :IDE
  
Synonyms : IDE / insulin degrading enzyme / P14735
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q23.33
Gene start: 92451684
Gene end: 92574076
  
Corresponding Affymetrix probe sets: 203327_at (Human Genome U133 Plus 2.0 Array)   203328_x_at (Human Genome U133 Plus 2.0 Array)   217496_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360637
Ensembl peptide - ENSP00000408850
Ensembl peptide - ENSP00000473506
Ensembl peptide - ENSP00000265986
NCBI entrez gene - 3416     See in Manteia.
OMIM - 146680
RefSeq - NM_001322797
RefSeq - NM_004969
RefSeq - XM_017016190
RefSeq - NM_001165946
RefSeq - NM_001322793
RefSeq - NM_001322794
RefSeq - NM_001322795
RefSeq - NM_001322796
RefSeq - XM_017016187
RefSeq - XM_017016188
RefSeq - XM_017016189
RefSeq Peptide - NP_001309725
RefSeq Peptide - NP_001309726
RefSeq Peptide - NP_004960
RefSeq Peptide - NP_001309722
RefSeq Peptide - NP_001309723
RefSeq Peptide - NP_001309724
RefSeq Peptide - NP_001159418
swissprot - P14735
swissprot - Q5T5N3
swissprot - R4GN65
Ensembl - ENSG00000119912
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ideENSDARG00000075570Danio rerio
 IDEENSGALG00000038924Gallus gallus
 IdeENSMUSG00000056999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NRDC / O43847 / nardilysin convertaseENSG0000007861833


Protein motifs (from Interpro)
Interpro ID Name
 IPR001431  Peptidase M16, zinc-binding site
 IPR007863  Peptidase M16, C-terminal
 IPR011249  Metalloenzyme, LuxS/M16 peptidase-like
 IPR011765  Peptidase M16, N-terminal
 IPR032632  Peptidase M16, middle/third domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008286 insulin receptor signaling pathway NAS
 biological_processGO:0008340 determination of adult lifespan IDA
 biological_processGO:0010815 bradykinin catabolic process IDA
 biological_processGO:0010992 ubiquitin recycling IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032461 positive regulation of protein oligomerization IDA
 biological_processGO:0042447 hormone catabolic process IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0045732 positive regulation of protein catabolic process TAS
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050435 amyloid-beta metabolic process IDA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0097242 amyloid-beta clearance ISS
 biological_processGO:1901142 insulin metabolic process IDA
 biological_processGO:1901143 insulin catabolic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005782 peroxisomal matrix IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031597 cytosolic proteasome complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0031626 beta-endorphin binding IEA
 molecular_functionGO:0042277 peptide binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043559 insulin binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140036 ubiquitin-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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