ENSMUSG00000056999


Mus musculus

Features
Gene ID: ENSMUSG00000056999
  
Biological name :Ide
  
Synonyms : Ide / insulin-degrading enzyme
  
Possible biological names infered from orthology : P14735
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C2
Gene start: 37268743
Gene end: 37337852
  
Corresponding Affymetrix probe sets: 10467230 (MoGene1.0st)   1423120_at (Mouse Genome 430 2.0 Array)   1423121_at (Mouse Genome 430 2.0 Array)   1435140_at (Mouse Genome 430 2.0 Array)   1441860_x_at (Mouse Genome 430 2.0 Array)   1453988_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121358
NCBI entrez gene - 15925     See in Manteia.
MGI - MGI:96412
RefSeq - NM_031156
RefSeq Peptide - NP_112419
swissprot - F6RPJ9
Ensembl - ENSMUSG00000056999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ideENSDARG00000075570Danio rerio
 IDEENSGALG00000038924Gallus gallus
 IDEENSG00000119912Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrd1 / Q8BHG1 / Mus musculus nardilysin, N-arginine dibasic convertase, NRD convertase 1 (Nrd1), transcript variant 3, mRNA. / NRDC* / O43847* / nardilysin convertase*ENSMUSG0000005351033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001431  Peptidase M16, zinc-binding site
 IPR007863  Peptidase M16, C-terminal
 IPR011249  Metalloenzyme, LuxS/M16 peptidase-like
 IPR011765  Peptidase M16, N-terminal
 IPR032632  Peptidase M16, middle/third domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0010815 bradykinin catabolic process IEA
 biological_processGO:0010992 ubiquitin recycling IEA
 biological_processGO:0032461 positive regulation of protein oligomerization IEA
 biological_processGO:0042447 hormone catabolic process IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0045861 negative regulation of proteolysis IEA
 biological_processGO:0050435 amyloid-beta metabolic process IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0097242 amyloid-beta clearance IEA
 biological_processGO:1901142 insulin metabolic process IEA
 biological_processGO:1901143 insulin catabolic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005782 peroxisomal matrix IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031597 cytosolic proteasome complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0031626 beta-endorphin binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043559 insulin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140036 ubiquitin-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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