ENSDARG00000075570


Danio rerio

Features
Gene ID: ENSDARG00000075570
  
Biological name :ide
  
Synonyms : ide / insulin-degrading enzyme
  
Possible biological names infered from orthology : P14735
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 42309688
Gene end: 42350160
  
Corresponding Affymetrix probe sets: Dr.14726.1.S1_at (Zebrafish Array)   Dr.14726.1.S1_a_at (Zebrafish Array)   Dr.14726.2.S1_at (Zebrafish Array)   Dr.5554.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000135107
NCBI entrez gene - 561390     See in Manteia.
RefSeq - NM_001089525
RefSeq - XM_005169527
RefSeq Peptide - NP_001082994
swissprot - A0A0R4IL71
ZFIN ID - ZDB-GENE-070410-85
Ensembl - ENSDARG00000075570
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IDEENSGALG00000038924Gallus gallus
 IDEENSG00000119912Homo sapiens
 IdeENSMUSG00000056999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nrd1b / nardilysin b (N-arginine dibasic convertase) / Nrd1* / NRDC* / Q8BHG1* / O43847* / nardilysin convertase* / Mus musculus nardilysin, N-arginine dibasic convertase, NRD convertase 1 ...ENSDARG0000006237232
nrd1a / nardilysin a (N-arginine dibasic convertase) / Nrd1* / NRDC* / Q8BHG1* / O43847* / nardilysin convertase* / Mus musculus nardilysin, N-arginine dibasic convertase, NRD convertase 1 ...ENSDARG0000001959632


Protein motifs (from Interpro)
Interpro ID Name
 IPR001431  Peptidase M16, zinc-binding site
 IPR007863  Peptidase M16, C-terminal
 IPR011249  Metalloenzyme, LuxS/M16 peptidase-like
 IPR011765  Peptidase M16, N-terminal
 IPR032632  Peptidase M16, middle/third domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003323 type B pancreatic cell development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:1990798 pancreas regeneration IMP
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001260 endocrine pancreas endocrine pancreas increased distribution , abnormal
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 ZFA:0009102 pancreatic B cell pancreatic B cell increased amount , abnormal
pancreatic B cell decreased amount , abnormal
pancreatic B cell decreased area , abnormal
pancreatic B cell regeneration decreased rate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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