ENSMUSG00000053510


Mus musculus

Features
Gene ID: ENSMUSG00000053510
  
Biological name :Nrd1
  
Synonyms : Mus musculus nardilysin, N-arginine dibasic convertase, NRD convertase 1 (Nrd1), transcript variant 3, mRNA. / Nrd1 / Q8BHG1
  
Possible biological names infered from orthology : nardilysin convertase / NRDC / O43847
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 109000655
Gene end: 109061777
  
Corresponding Affymetrix probe sets: 10506893 (MoGene1.0st)   1424391_at (Mouse Genome 430 2.0 Array)   1449716_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122808
Ensembl peptide - ENSMUSP00000068328
Ensembl peptide - ENSMUSP00000099797
Ensembl peptide - ENSMUSP00000102255
NCBI entrez gene - 230598     See in Manteia.
MGI - MGI:1201386
RefSeq - XM_017320144
RefSeq - NM_001346554
RefSeq - NM_146150
RefSeq - XM_006502990
RefSeq - XM_006502991
RefSeq Peptide - NP_666262
RefSeq Peptide - NP_001334098
RefSeq Peptide - NP_001333483
swissprot - A2A9Q2
swissprot - A6PWC3
swissprot - Q3V3G9
swissprot - Q8BHG1
Ensembl - ENSMUSG00000053510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrd1aENSDARG00000019596Danio rerio
 nrd1bENSDARG00000062372Danio rerio
 NRDCENSGALG00000010565Gallus gallus
 NRDCENSG00000078618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ide / insulin-degrading enzyme / P14735*ENSMUSG0000005699927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001431  Peptidase M16, zinc-binding site
 IPR007863  Peptidase M16, C-terminal
 IPR011249  Metalloenzyme, LuxS/M16 peptidase-like
 IPR011765  Peptidase M16, N-terminal
 IPR032632  Peptidase M16, middle/third domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis ISO
 biological_processGO:0052548 regulation of endopeptidase activity ISO
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity ISO
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0002651 abnormal sciatic nerve "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

Allelic Composition: Nrd1tm1Eiin/Nrd1+
Genetic Background: B6.Cg-Nrd1tm1Eiin

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

Allelic Composition: Nrd1tm1Eiin/Nrd1+
Genetic Background: B6.Cg-Nrd1tm1Eiin

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

Allelic Composition: Nrd1tm1Eiin/Nrd1+
Genetic Background: B6.Cg-Nrd1tm1Eiin

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sncatm1Rosl/Sncatm1Rosl
Genetic Background: B6.129X1-Sncatm1Rosl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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