ENSG00000079459


Homo sapiens

Features
Gene ID: ENSG00000079459
  
Biological name :FDFT1
  
Synonyms : farnesyl-diphosphate farnesyltransferase 1 / FDFT1 / P37268
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p23.1
Gene start: 11795573
Gene end: 11839309
  
Corresponding Affymetrix probe sets: 208647_at (Human Genome U133 Plus 2.0 Array)   210950_s_at (Human Genome U133 Plus 2.0 Array)   238666_at (Human Genome U133 Plus 2.0 Array)   241954_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434770
Ensembl peptide - ENSP00000435900
Ensembl peptide - ENSP00000491537
Ensembl peptide - ENSP00000485229
Ensembl peptide - ENSP00000484122
Ensembl peptide - ENSP00000481481
Ensembl peptide - ENSP00000480828
Ensembl peptide - ENSP00000444248
Ensembl peptide - ENSP00000436069
Ensembl peptide - ENSP00000220584
Ensembl peptide - ENSP00000390367
Ensembl peptide - ENSP00000431649
Ensembl peptide - ENSP00000431749
Ensembl peptide - ENSP00000431852
Ensembl peptide - ENSP00000432331
Ensembl peptide - ENSP00000432551
Ensembl peptide - ENSP00000433985
Ensembl peptide - ENSP00000434714
NCBI entrez gene - 2222     See in Manteia.
OMIM - 184420
RefSeq - XM_017013217
RefSeq - NM_001287742
RefSeq - NM_001287743
RefSeq - NM_001287744
RefSeq - NM_001287745
RefSeq - NM_001287747
RefSeq - NM_001287748
RefSeq - NM_001287749
RefSeq - NM_001287750
RefSeq - NM_001287751
RefSeq - NM_001287756
RefSeq - NM_004462
RefSeq Peptide - NP_001274680
RefSeq Peptide - NP_001274685
RefSeq Peptide - NP_004453
RefSeq Peptide - NP_001274671
RefSeq Peptide - NP_001274672
RefSeq Peptide - NP_001274673
RefSeq Peptide - NP_001274674
RefSeq Peptide - NP_001274676
RefSeq Peptide - NP_001274677
RefSeq Peptide - NP_001274678
RefSeq Peptide - NP_001274679
swissprot - E9PNM1
swissprot - P37268
swissprot - Q6IAX1
swissprot - E9PSH1
swissprot - E9PNJ2
swissprot - E9PJG4
swissprot - A0A1W2PQ47
swissprot - E9PS69
swissprot - E9PQ90
Ensembl - ENSG00000079459
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fdft1ENSDARG00000101062Danio rerio
 FDFT1ENSGALG00000016665Gallus gallus
 Fdft1ENSMUSG00000021273Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002060  Squalene/phytoene synthase
 IPR006449  Squalene synthase-like
 IPR008949  Isoprenoid synthase domain superfamily
 IPR019845  Squalene/phytoene synthase, conserved site
 IPR033904  Trans-Isoprenyl Diphosphate Synthases, head-to-head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process TAS
 biological_processGO:0006695 cholesterol biosynthetic process IBA
 biological_processGO:0006696 ergosterol biosynthetic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008299 isoprenoid biosynthetic process IEA
 biological_processGO:0008610 lipid biosynthetic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0045338 farnesyl diphosphate metabolic process IBA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004310 farnesyl-diphosphate farnesyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
 molecular_functionGO:0051996 squalene synthase activity IBA


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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