ENSG00000085999


Homo sapiens

Features
Gene ID: ENSG00000085999
  
Biological name :RAD54L
  
Synonyms : Q92698 / RAD54L / RAD54 like
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.1
Gene start: 46247688
Gene end: 46278473
  
Corresponding Affymetrix probe sets: 204558_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477172
Ensembl peptide - ENSP00000477729
Ensembl peptide - ENSP00000483843
Ensembl peptide - ENSP00000480207
Ensembl peptide - ENSP00000479995
Ensembl peptide - ENSP00000479823
Ensembl peptide - ENSP00000479734
Ensembl peptide - ENSP00000479155
Ensembl peptide - ENSP00000361043
Ensembl peptide - ENSP00000396113
Ensembl peptide - ENSP00000476642
NCBI entrez gene - 8438     See in Manteia.
OMIM - 603615
RefSeq - NM_001142548
RefSeq - XM_011542300
RefSeq - XM_011542299
RefSeq - XM_006710975
RefSeq - NM_003579
RefSeq Peptide - NP_001136020
RefSeq Peptide - NP_003570
swissprot - A0A087WV39
swissprot - A0A087X124
swissprot - A0A087WWG5
swissprot - Q92698
swissprot - V9GYD3
swissprot - V9GYX6
swissprot - A0A087WVW5
swissprot - A0A087WW72
swissprot - A0A087WTB0
Ensembl - ENSG00000085999
  
Related genetic diseases (OMIM): 114480 - {Breast cancer, invasive ductal}, 114480
  603615 - Adenocarcinoma, colonic, somatic
  605027 - Lymphoma, non-Hodgkin, somatic, 605027
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad54lENSDARG00000018623Danio rerio
 RAD54LENSGALG00000010356Gallus gallus
 P70270ENSMUSG00000028702Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y620 / RAD54B / RAD54 homolog B (S. cerevisiae)ENSG0000019727542
FSBP / O95073 / fibrinogen silencer binding proteinENSG0000026581740
ATRX / P46100 / ATRX, chromatin remodelerENSG0000008522429
Q9Y4B4 / RAD54L2 / RAD54 like 2ENSG0000016408027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0000733 DNA strand renaturation IEA
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006302 double-strand break repair IEA
 biological_processGO:0006310 DNA recombination TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008340 determination of adult lifespan IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051321 meiotic cell cycle TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036310 annealing helicase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0002665 Lymphoma "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." [HPO:curators]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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