ENSG00000197275


Homo sapiens

Features
Gene ID: ENSG00000197275
  
Biological name :RAD54B
  
Synonyms : Q9Y620 / RAD54B / RAD54 homolog B (S. cerevisiae)
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q22.1
Gene start: 94371960
Gene end: 94475109
  
Corresponding Affymetrix probe sets: 219494_at (Human Genome U133 Plus 2.0 Array)   220549_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000336606
Ensembl peptide - ENSP00000430808
Ensembl peptide - ENSP00000430570
Ensembl peptide - ENSP00000430153
Ensembl peptide - ENSP00000428554
NCBI entrez gene - 25788     See in Manteia.
OMIM - 604289
RefSeq - NM_012415
RefSeq - NM_001205262
RefSeq Peptide - NP_001192191
RefSeq Peptide - NP_036547
swissprot - Q9Y620
swissprot - E5RI14
swissprot - E5RHN9
swissprot - E5RJF7
Ensembl - ENSG00000197275
  
Related genetic diseases (OMIM): 114500 - Colon cancer, somatic, 114500
  605027 - Lymphoma, non-Hodgkin, somatic, 605027
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad54bENSDARG00000092134Danio rerio
 RAD54BENSGALG00000043597Gallus gallus
 Q6PFE3ENSMUSG00000078773Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FSBP / O95073 / fibrinogen silencer binding proteinENSG0000026581780
Q92698 / RAD54L / RAD54 likeENSG0000008599935
ATRX / P46100 / ATRX, chromatin remodelerENSG0000008522426
Q9Y4B4 / RAD54L2 / RAD54 like 2ENSG0000016408022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006312 mitotic recombination TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007131 reciprocal meiotic recombination TAS
 biological_processGO:0032508 DNA duplex unwinding IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003678 DNA helicase activity TAS
 molecular_functionGO:0003724 RNA helicase activity TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015616 DNA translocase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0002665 Lymphoma "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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