ENSMUSG00000078773


Mus musculus

Features
Gene ID: ENSMUSG00000078773
  
Biological name :Rad54b
  
Synonyms : DNA repair and recombination protein RAD54B / Q6PFE3 / Rad54b
  
Possible biological names infered from orthology : fibrinogen silencer binding protein / FSBP / O95073 / Q9Y620 / RAD54 homolog B (S. cerevisiae)
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 11558922
Gene end: 11615805
  
Corresponding Affymetrix probe sets: 10503315 (MoGene1.0st)   1434734_at (Mouse Genome 430 2.0 Array)   1443318_at (Mouse Genome 430 2.0 Array)   1456674_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136561
Ensembl peptide - ENSMUSP00000066977
Ensembl peptide - ENSMUSP00000092767
Ensembl peptide - ENSMUSP00000103942
NCBI entrez gene - 623474     See in Manteia.
MGI - MGI:3605986
RefSeq - NM_001039556
RefSeq - NM_001256145
RefSeq Peptide - NP_001034645
RefSeq Peptide - NP_001243074
swissprot - Q6PFE3
swissprot - A0A0A0MQB1
swissprot - A2AIU9
swissprot - J3QN23
Ensembl - ENSMUSG00000078773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad54bENSDARG00000092134Danio rerio
 RAD54BENSGALG00000043597Gallus gallus
 FSBPENSG00000265817Homo sapiens
 Q9Y620ENSG00000197275Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70270 / Rad54l / DNA repair and recombination protein RAD54-like / Q92698* / RAD54 like*ENSMUSG0000002870236
Atrx / Q61687 / Transcriptional regulator ATRX / P46100* / ATRX, chromatin remodeler*ENSMUSG0000003122925
Rad54l2 / RAD54 like 2 (S. cerevisiae) / Q9Y4B4* / RAD54 like 2*ENSMUSG0000004066123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination ISO
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0008340 determination of adult lifespan IGI
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0042493 response to drug IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015616 DNA translocase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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