ENSMUSG00000028702


Mus musculus

Features
Gene ID: ENSMUSG00000028702
  
Biological name :Rad54l
  
Synonyms : DNA repair and recombination protein RAD54-like / P70270 / Rad54l
  
Possible biological names infered from orthology : Q92698 / RAD54 like
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 116094264
Gene end: 116123690
  
Corresponding Affymetrix probe sets: 10515257 (MoGene1.0st)   1423123_at (Mouse Genome 430 2.0 Array)   1423124_x_at (Mouse Genome 430 2.0 Array)   1450862_at (Mouse Genome 430 2.0 Array)   1453926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099765
Ensembl peptide - ENSMUSP00000099766
NCBI entrez gene - 19366     See in Manteia.
MGI - MGI:894697
RefSeq - XM_006502879
RefSeq - NM_001122958
RefSeq - NM_001122959
RefSeq - NM_009015
RefSeq - XM_006502877
RefSeq - XM_006502878
RefSeq Peptide - NP_001116430
RefSeq Peptide - NP_001116431
RefSeq Peptide - NP_033041
swissprot - P70270
Ensembl - ENSMUSG00000028702
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad54lENSDARG00000018623Danio rerio
 RAD54LENSGALG00000010356Gallus gallus
 Q92698ENSG00000085999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PFE3 / Rad54b / DNA repair and recombination protein RAD54B / FSBP* / O95073* / Q9Y620* / RAD54 homolog B (S. cerevisiae)* / fibrinogen silencer binding protein*ENSMUSG0000007877342
Atrx / Q61687 / Transcriptional regulator ATRX / P46100* / ATRX, chromatin remodeler*ENSMUSG0000003122929
Rad54l2 / RAD54 like 2 (S. cerevisiae) / Q9Y4B4* / RAD54 like 2*ENSMUSG0000004066127


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0000733 DNA strand renaturation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IGI
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0008340 determination of adult lifespan IGI
 biological_processGO:0010212 response to ionizing radiation IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0051276 chromosome organization IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036310 annealing helicase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Prkdctm1Get/Prkdctm1Get,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arsatm1Gie/Arsatm1Gie
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Rad54btm1Roka/Rad54btm1Roka,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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