ENSG00000100219


Homo sapiens

Features
Gene ID: ENSG00000100219
  
Biological name :XBP1
  
Synonyms : P17861 / X-box binding protein 1 / XBP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q12.1
Gene start: 28794555
Gene end: 28800597
  
Corresponding Affymetrix probe sets: 200670_at (Human Genome U133 Plus 2.0 Array)   242021_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000343155
Ensembl peptide - ENSP00000481170
Ensembl peptide - ENSP00000385162
Ensembl peptide - ENSP00000384295
Ensembl peptide - ENSP00000216037
NCBI entrez gene - 7494     See in Manteia.
OMIM - 194355
RefSeq - NM_005080
RefSeq - NM_001079539
RefSeq Peptide - NP_001073007
RefSeq Peptide - NP_005071
swissprot - P17861
swissprot - B1AHH1
swissprot - A0A024R1F0
swissprot - B1AHH2
Ensembl - ENSG00000100219
  
Related genetic diseases (OMIM): 612371 - {Major affective disorder-7, susceptibility to}, 612371

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xbp1ENSDARG00000035622Danio rerio
 XBP1ENSGALG00000005796Gallus gallus
 Xbp1ENSMUSG00000020484Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0001889 liver development ISS
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0002070 epithelial cell maturation IEA
 biological_processGO:0002639 positive regulation of immunoglobulin production IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process TAS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0010832 negative regulation of myotube differentiation ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response ISS
 biological_processGO:0031017 exocrine pancreas development IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0031670 cellular response to nutrient ISS
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0035356 cellular triglyceride homeostasis ISS
 biological_processGO:0035470 positive regulation of vascular wound healing IDA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0036500 ATF6-mediated unfolded protein response TAS
 biological_processGO:0042149 cellular response to glucose starvation ISS
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042632 cholesterol homeostasis ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IMP
 biological_processGO:0045579 positive regulation of B cell differentiation IDA
 biological_processGO:0045582 positive regulation of T cell differentiation IDA
 biological_processGO:0045600 positive regulation of fat cell differentiation ISS
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048666 neuron development ISS
 biological_processGO:0051024 positive regulation of immunoglobulin secretion ISS
 biological_processGO:0055089 fatty acid homeostasis ISS
 biological_processGO:0055092 sterol homeostasis ISS
 biological_processGO:0060612 adipose tissue development ISS
 biological_processGO:0060691 epithelial cell maturation involved in salivary gland development IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071230 cellular response to amino acid stimulus ISS
 biological_processGO:0071332 cellular response to fructose stimulus ISS
 biological_processGO:0071333 cellular response to glucose stimulus ISS
 biological_processGO:0071353 cellular response to interleukin-4 ISS
 biological_processGO:0071375 cellular response to peptide hormone stimulus ISS
 biological_processGO:1900100 positive regulation of plasma cell differentiation IDA
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IMP
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
 biological_processGO:1903489 positive regulation of lactation ISS
 biological_processGO:1990418 response to insulin-like growth factor stimulus ISS
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation ISS
 biological_processGO:2000778 positive regulation of interleukin-6 secretion ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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