ENSMUSG00000020484


Mus musculus

Features
Gene ID: ENSMUSG00000020484
  
Biological name :Xbp1
  
Synonyms : O35426 / X-box binding protein 1 / Xbp1
  
Possible biological names infered from orthology : P17861
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 5520659
Gene end: 5525893
  
Corresponding Affymetrix probe sets: 10374035 (MoGene1.0st)   1420011_s_at (Mouse Genome 430 2.0 Array)   1420012_at (Mouse Genome 430 2.0 Array)   1420886_a_at (Mouse Genome 430 2.0 Array)   1437223_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054852
Ensembl peptide - ENSMUSP00000134088
Ensembl peptide - ENSMUSP00000135768
NCBI entrez gene - 22433     See in Manteia.
MGI - MGI:98970
RefSeq - NM_013842
RefSeq - NM_001271730
RefSeq Peptide - NP_001258659
RefSeq Peptide - NP_038870
swissprot - O35426
swissprot - H3BLF6
swissprot - G3UYH6
Ensembl - ENSMUSG00000020484
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xbp1ENSDARG00000035622Danio rerio
 XBP1ENSGALG00000005796Gallus gallus
 XBP1ENSG00000100219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0001935 endothelial cell proliferation ISO
 biological_processGO:0002070 epithelial cell maturation IMP
 biological_processGO:0002639 positive regulation of immunoglobulin production IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0010508 positive regulation of autophagy ISS
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016049 cell growth ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0031017 exocrine pancreas development IMP
 biological_processGO:0031062 positive regulation of histone methylation ISO
 biological_processGO:0031647 regulation of protein stability ISO
 biological_processGO:0031648 protein destabilization ISS
 biological_processGO:0032008 positive regulation of TOR signaling ISO
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0035356 cellular triglyceride homeostasis IMP
 biological_processGO:0035470 positive regulation of vascular wound healing IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISO
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway ISO
 biological_processGO:0055089 fatty acid homeostasis IMP
 biological_processGO:0055092 sterol homeostasis IMP
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0060691 epithelial cell maturation involved in salivary gland development IMP
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IDA
 biological_processGO:0071498 cellular response to fluid shear stress ISS
 biological_processGO:0071499 cellular response to laminar fluid shear stress ISO
 biological_processGO:1900100 positive regulation of plasma cell differentiation IEA
 biological_processGO:1900102 negative regulation of endoplasmic reticulum unfolded protein response ISO
 biological_processGO:1900103 positive regulation of endoplasmic reticulum unfolded protein response IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IDA
 biological_processGO:1901985 positive regulation of protein acetylation ISO
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903489 positive regulation of lactation IMP
 biological_processGO:1990418 response to insulin-like growth factor stimulus IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IMP
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0031490 chromatin DNA binding ISS
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000233 abnormal blood flow velocity "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Wap-cre)11738Mam/0
Genetic Background: FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Wap-cre)11738Mam/0
Genetic Background: FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: GabarapGt(OST31915)Lex/GabarapGt(OST31915)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: GabarapGt(OST31915)Lex/GabarapGt(OST31915)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: GabarapGt(OST31915)Lex/GabarapGt(OST31915)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: GabarapGt(OST31915)Lex/GabarapGt(OST31915)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: GabarapGt(OST31915)Lex/GabarapGt(OST31915)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Wap-cre)11738Mam/0
Genetic Background: FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002316 anoxia "absence or almost complete absence of oxygen from inspired gases, blood, or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

Allelic Composition: Xbp1tm2Glm/Xbp1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL

Allelic Composition: Xbp1tm3Glm/Xbp1tm3Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Defa6-icre)1Rsb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Defa6-icre)1Rsb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Ern1tm2.1Tiw/Ern1tm2.1Tiw,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Wap-cre)11738Mam/0
Genetic Background: FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: GabarapGt(OST31915)Lex/GabarapGt(OST31915)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Xbp1tm1.2Geno/Xbp1tm1.2Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: GabarapGt(OST31915)Lex/GabarapGt(OST31915)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xbp1tm1Glm/Xbp1tm1Glm
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Xbp1tm1.2Geno/Xbp1tm1.2Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Xbp1tm1Glm/Xbp1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ern1tm1Tiw/Ern1tm1Tiw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Defa6-icre)1Rsb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Wap-cre)11738Mam/0
Genetic Background: FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005363 decreased susceptibility to prion infection "reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sox2tm2Lpev/Sox2tm3Lpev
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Wap-cre)11738Mam/0
Genetic Background: FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Xbp1tm2Glm/Xbp1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008142 decreased small intestinal villus size "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Xbp1tm3Glm/Xbp1tm3Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Defa6-icre)1Rsb/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0008882 abnormal enterocyte physiology "any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen" [CL:0000584, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Xbp1tm1.2Geno/Xbp1tm1.2Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg16l1tm1.1Geno/Atg16l1tm1.1Geno,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Xbp1tm2Glm/Xbp1tm2Glm,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Wap-cre)11738Mam/0
Genetic Background: FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

Allelic Composition: Xbp1tm3Glm/Xbp1tm3Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Xbp1tm1Glm/Xbp1tm1Glm
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Xbp1tm1.2Geno/Xbp1tm1.2Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nsd3tm1b(EUCOMM)Hmgu/Nsd3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Nsd3tm1b(EUCOMM)Hmgu/H

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013486 decreased Paneth cell number "fewer than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Xbp1tm3Glm/Xbp1tm3Glm,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0013792 abnormal small intestine goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

 MP:0014076 absent Paneth cells "absence or loss of the large secretory cells containing coarse granules normally confined to the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+,Mfn1tm2Dcc/Mfn1tm2Dcc,Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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