ENSG00000100344


Homo sapiens

Features
Gene ID: ENSG00000100344
  
Biological name :PNPLA3
  
Synonyms : patatin like phospholipase domain containing 3 / PNPLA3 / Q9NST1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.31
Gene start: 43923739
Gene end: 43964488
  
Corresponding Affymetrix probe sets: 220675_s_at (Human Genome U133 Plus 2.0 Array)   233030_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397987
Ensembl peptide - ENSP00000216180
Ensembl peptide - ENSP00000384668
NCBI entrez gene - 80339     See in Manteia.
OMIM - 609567
RefSeq - NM_025225
RefSeq Peptide - NP_079501
swissprot - F8W8E5
swissprot - Q9NST1
Ensembl - ENSG00000100344
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Pnpla3ENSMUSG00000041653Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PNPLA2 / Q96AD5 / patatin like phospholipase domain containing 2ENSG0000017766638
PNPLA5 / Q7Z6Z6 / patatin like phospholipase domain containing 5ENSG0000010034132
PNPLA1 / Q8N8W4 / patatin like phospholipase domain containing 1ENSG0000018031628
P41247 / PNPLA4 / patatin like phospholipase domain containing 4ENSG0000000675718


Protein motifs (from Interpro)
Interpro ID Name
 IPR002641  Patatin-like phospholipase domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase
 IPR033562  Patatin-like phospholipase domain-containing protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006650 glycerophospholipid metabolic process IDA
 biological_processGO:0006654 phosphatidic acid biosynthetic process IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019432 triglyceride biosynthetic process IDA
 biological_processGO:0019433 triglyceride catabolic process IEA
 biological_processGO:0034389 lipid particle organization IMP
 biological_processGO:0036153 triglyceride acyl-chain remodeling IDA
 biological_processGO:0036155 acylglycerol acyl-chain remodeling TAS
 biological_processGO:0055088 lipid homeostasis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005811 lipid droplet IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004465 lipoprotein lipase activity TAS
 molecular_functionGO:0004623 phospholipase A2 activity IDA
 molecular_functionGO:0004806 triglyceride lipase activity TAS
 molecular_functionGO:0016411 acylglycerol O-acyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035727 lysophosphatidic acid binding IDA
 molecular_functionGO:0036042 long-chain fatty acyl-CoA binding IDA
 molecular_functionGO:0042171 lysophosphatidic acid acyltransferase activity IDA
 molecular_functionGO:0051264 mono-olein transacylation activity IDA
 molecular_functionGO:0051265 diolein transacylation activity IDA


Pathways (from Reactome)
Pathway description
Acyl chain remodeling of DAG and TAG


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr