ENSG00000102978


Homo sapiens

Features
Gene ID: ENSG00000102978
  
Biological name :POLR2C
  
Synonyms : P19387 / POLR2C / RNA polymerase II subunit C
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q21
Gene start: 57462387
Gene end: 57472010
  
Corresponding Affymetrix probe sets: 208996_s_at (Human Genome U133 Plus 2.0 Array)   214263_x_at (Human Genome U133 Plus 2.0 Array)   216282_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000219252
Ensembl peptide - ENSP00000456367
NCBI entrez gene - 5432     See in Manteia.
OMIM - 180663
RefSeq - NM_032940
RefSeq Peptide - NP_116558
swissprot - Q6FGR6
swissprot - H3BRR2
swissprot - P19387
Ensembl - ENSG00000102978
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polr2cENSDARG00000033596Danio rerio
 POLR2CENSGALG00000001168Gallus gallus
 P97760ENSMUSG00000031783Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001514  DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
 IPR011262  DNA-directed RNA polymerase, insert domain
 IPR011263  DNA-directed RNA polymerase, RpoA/D/Rpb3-type
 IPR036603  RNA polymerase, RBP11-like subunit
 IPR036643  DNA-directed RNA polymerase, insert domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway TAS
 biological_processGO:0016070 RNA metabolic process TAS
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0050434 positive regulation of viral transcription TAS
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005665 DNA-directed RNA polymerase II, core complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 molecular_functionGO:0001055 RNA polymerase II activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation of pluripotent stem cells
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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