ENSG00000105223


Homo sapiens

Features
Gene ID: ENSG00000105223
  
Biological name :PLD3
  
Synonyms : phospholipase D family member 3 / PLD3 / Q8IV08
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 40348456
Gene end: 40380439
  
Corresponding Affymetrix probe sets: 201050_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471838
Ensembl peptide - ENSP00000470603
Ensembl peptide - ENSP00000472509
Ensembl peptide - ENSP00000473218
Ensembl peptide - ENSP00000472854
Ensembl peptide - ENSP00000348901
Ensembl peptide - ENSP00000352220
Ensembl peptide - ENSP00000375886
Ensembl peptide - ENSP00000386293
Ensembl peptide - ENSP00000386938
Ensembl peptide - ENSP00000387022
Ensembl peptide - ENSP00000387050
Ensembl peptide - ENSP00000468898
Ensembl peptide - ENSP00000468999
Ensembl peptide - ENSP00000469675
Ensembl peptide - ENSP00000469868
NCBI entrez gene - 23646     See in Manteia.
OMIM - 615698
RefSeq - XM_017026549
RefSeq - NM_001031696
RefSeq - NM_001291311
RefSeq - NM_012268
RefSeq - XM_005258704
RefSeq - XM_005258707
RefSeq - XM_005258708
RefSeq - XM_005258709
RefSeq - XM_005258710
RefSeq - XM_006723122
RefSeq - XM_011526692
RefSeq - XM_011526693
RefSeq - XM_017026546
RefSeq - XM_017026547
RefSeq - XM_017026548
RefSeq Peptide - NP_036400
RefSeq Peptide - NP_001278240
RefSeq Peptide - NP_001026866
swissprot - M0QX50
swissprot - M0QX99
swissprot - M0QY94
swissprot - M0QYJ4
swissprot - M0QZK2
swissprot - M0R1F7
swissprot - M0R2E7
swissprot - M0R2W7
swissprot - M0R3G9
swissprot - Q8IV08
swissprot - A0A024R0Q4
swissprot - E2QRG1
swissprot - A0A0A0MS28
Ensembl - ENSG00000105223
  
Related genetic diseases (OMIM): 617770 - ?Spinocerebellar ataxia 46, 617770
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pld3ENSDARG00000068199Danio rerio
 Pld3ENSMUSG00000003363Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLD4 / Q96BZ4 / phospholipase D family member 4ENSG0000016642842
PLD5 / Q8N7P1 / phospholipase D family member 5ENSG0000018028733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001736  Phospholipase D/Transphosphatidylase
 IPR025202  Phospholipase D-like domain
 IPR032803  PLD-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004630 phospholipase D activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PG
Role of phospholipids in phagocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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