ENSG00000105550


Homo sapiens

Features
Gene ID: ENSG00000105550
  
Biological name :FGF21
  
Synonyms : FGF21 / fibroblast growth factor 21 / Q9NSA1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 48755559
Gene end: 48758333
  
Corresponding Affymetrix probe sets: 221433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471477
Ensembl peptide - ENSP00000222157
NCBI entrez gene - 26291     See in Manteia.
OMIM - 609436
RefSeq - NM_019113
RefSeq Peptide - NP_061986
swissprot - Q9NSA1
Ensembl - ENSG00000105550
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fgf21ENSMUSG00000030827Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF19 / O95750 / fibroblast growth factor 19ENSG0000016234431
FGF23 / Q9GZV9 / fibroblast growth factor 23ENSG0000011897230


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028292  Fibroblast growth factor 21
 IPR035444  Fibroblast growth factor 15/19/21


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010898 positive regulation of triglyceride catabolic process IEA
 biological_processGO:0010988 regulation of low-density lipoprotein particle clearance NAS
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process NAS
 biological_processGO:0046326 positive regulation of glucose import IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0072577 endothelial cell apoptotic process IEA
 biological_processGO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1904640 response to methionine IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Cellular hexose transport
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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