ENSG00000105968


Homo sapiens

Features
Gene ID: ENSG00000105968
  
Biological name :H2AFV
  
Synonyms : H2AFV / H2A histone family member V / Q71UI9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p13
Gene start: 44826791
Gene end: 44848083
  
Corresponding Affymetrix probe sets: 202487_s_at (Human Genome U133 Plus 2.0 Array)   212205_at (Human Genome U133 Plus 2.0 Array)   212206_s_at (Human Genome U133 Plus 2.0 Array)   227085_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370516
Ensembl peptide - ENSP00000430492
Ensembl peptide - ENSP00000406901
Ensembl peptide - ENSP00000397115
Ensembl peptide - ENSP00000222690
Ensembl peptide - ENSP00000308405
Ensembl peptide - ENSP00000340708
Ensembl peptide - ENSP00000342714
NCBI entrez gene - 94239     See in Manteia.
RefSeq - NM_201436
RefSeq - NM_201516
RefSeq - NM_201517
RefSeq - NM_012412
RefSeq - NM_138635
RefSeq Peptide - NP_619541
RefSeq Peptide - NP_958924
RefSeq Peptide - NP_958925
RefSeq Peptide - NP_036544
RefSeq Peptide - NP_958844
swissprot - Q71UI9
swissprot - C9J386
swissprot - C9J0D1
swissprot - E5RJU1
Ensembl - ENSG00000105968
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h2afvaENSDARG00000068820Danio rerio
 H2afvENSMUSG00000041126Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2AFZ / P0C0S5 / H2A histone family member ZENSG0000016403298


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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