ENSG00000164032


Homo sapiens

Features
Gene ID: ENSG00000164032
  
Biological name :H2AFZ
  
Synonyms : H2AFZ / H2A histone family member Z / P0C0S5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q23
Gene start: 99948086
Gene end: 99950388
  
Corresponding Affymetrix probe sets: 200853_at (Human Genome U133 Plus 2.0 Array)   213911_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296417
NCBI entrez gene - 3015     See in Manteia.
OMIM - 142763
RefSeq - NM_002106
RefSeq Peptide - NP_002097
swissprot - P0C0S5
Ensembl - ENSG00000164032
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h2afvbENSDARG00000116491Danio rerio
 H2afzENSMUSG00000037894Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2AFV / Q71UI9 / H2A histone family member VENSG0000010596898


Protein motifs (from Interpro)
Interpro ID Name
 IPR002119  Histone H2A
 IPR007125  Histone H2A/H2B/H3
 IPR009072  Histone-fold
 IPR032454  Histone H2A, C-terminal domain
 IPR032458  Histone H2A conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006342 chromatin silencing IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0071392 cellular response to estradiol stimulus IMP
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005720 nuclear heterochromatin IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031490 chromatin DNA binding IDA
 molecular_functionGO:0031492 nucleosomal DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Chain Elongation
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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