ENSG00000107581


Homo sapiens

Features
Gene ID: ENSG00000107581
  
Biological name :EIF3A
  
Synonyms : EIF3A / eukaryotic translation initiation factor 3 subunit A / Q14152
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q26.11
Gene start: 119033670
Gene end: 119080823
  
Corresponding Affymetrix probe sets: 200595_s_at (Human Genome U133 Plus 2.0 Array)   200596_s_at (Human Genome U133 Plus 2.0 Array)   200597_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000438178
Ensembl peptide - ENSP00000358140
NCBI entrez gene - 8661     See in Manteia.
OMIM - 602039
RefSeq - NM_003750
RefSeq Peptide - NP_003741
swissprot - Q14152
Ensembl - ENSG00000107581
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6PCR7ENSDARG00000076815Danio rerio
 ENSGALG00000009328Gallus gallus
 ENSGALG00000041242Gallus gallus
 Eif3aENSMUSG00000024991Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR027512  Eukaryotic translation initiation factor 3 subunit A
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001732 formation of cytoplasmic translation initiation complex IDA
 biological_processGO:0002188 translation reinitiation IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0075522 IRES-dependent viral translational initiation IDA
 biological_processGO:0075525 viral translational termination-reinitiation IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm NAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex IDA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0043614 multi-eIF complex IBA
 cellular_componentGO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e IBA
 cellular_componentGO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IBA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IBA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005198 structural molecule activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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