ENSG00000111596


Homo sapiens

Features
Gene ID: ENSG00000111596
  
Biological name :CNOT2
  
Synonyms : CCR4-NOT transcription complex subunit 2 / CNOT2 / Q9NZN8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q15
Gene start: 70242994
Gene end: 70354993
  
Corresponding Affymetrix probe sets: 217798_at (Human Genome U133 Plus 2.0 Array)   222181_at (Human Genome U133 Plus 2.0 Array)   222182_s_at (Human Genome U133 Plus 2.0 Array)   233054_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450283
Ensembl peptide - ENSP00000450090
Ensembl peptide - ENSP00000450318
Ensembl peptide - ENSP00000483096
Ensembl peptide - ENSP00000229195
Ensembl peptide - ENSP00000412091
Ensembl peptide - ENSP00000446507
Ensembl peptide - ENSP00000447497
Ensembl peptide - ENSP00000447808
Ensembl peptide - ENSP00000447813
Ensembl peptide - ENSP00000448024
Ensembl peptide - ENSP00000448255
Ensembl peptide - ENSP00000448298
Ensembl peptide - ENSP00000448453
Ensembl peptide - ENSP00000448490
Ensembl peptide - ENSP00000448660
Ensembl peptide - ENSP00000448808
Ensembl peptide - ENSP00000448883
Ensembl peptide - ENSP00000449084
Ensembl peptide - ENSP00000449260
Ensembl peptide - ENSP00000449385
Ensembl peptide - ENSP00000449446
Ensembl peptide - ENSP00000449577
Ensembl peptide - ENSP00000449659
Ensembl peptide - ENSP00000449801
Ensembl peptide - ENSP00000449917
Ensembl peptide - ENSP00000450077
NCBI entrez gene - 4848     See in Manteia.
OMIM - 604909
RefSeq - XM_017019354
RefSeq - NM_001199302
RefSeq - NM_001199303
RefSeq - NM_014515
RefSeq - XM_006719429
RefSeq - XM_006719430
RefSeq - XM_006719432
RefSeq - XM_006719433
RefSeq - XM_011538399
RefSeq - XM_011538400
RefSeq - XM_017019348
RefSeq - XM_017019349
RefSeq - XM_017019350
RefSeq - XM_017019351
RefSeq - XM_017019352
RefSeq - XM_017019353
RefSeq Peptide - NP_055330
RefSeq Peptide - NP_001186231
RefSeq Peptide - NP_001186232
swissprot - H0YHT6
swissprot - H0YHT8
swissprot - H0YI11
swissprot - H0YI80
swissprot - Q9NZN8
swissprot - A0A024RBD8
swissprot - A0A087X050
swissprot - F8VP97
swissprot - F8VPX5
swissprot - F8VQD8
swissprot - F8VQF4
swissprot - F8VRJ3
swissprot - F8VRS8
swissprot - F8VS14
swissprot - F8VSK9
swissprot - F8VUB4
swissprot - F8VV05
swissprot - F8VV52
swissprot - F8VVD4
swissprot - F8VVY1
swissprot - F8VX63
swissprot - F8VWH8
swissprot - F8W145
swissprot - H0YH84
Ensembl - ENSG00000111596
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnot2ENSDARG00000061802Danio rerio
 CNOT2ENSGALG00000010042Gallus gallus
 Cnot2ENSMUSG00000020166Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007282  NOT2/NOT3/NOT5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
 biological_processGO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II NAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010606 positive regulation of cytoplasmic mRNA processing body assembly IMP
 biological_processGO:0017148 negative regulation of translation IBA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IMP
 cellular_componentGO:0000932 P-body IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030014 CCR4-NOT complex IDA
 cellular_componentGO:0030015 CCR4-NOT core complex IBA
 molecular_functionGO:0001226 RNA polymerase II transcription corepressor binding IDA
 molecular_functionGO:0004535 poly(A)-specific ribonuclease activity IMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Deadenylation of mRNA
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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