ENSG00000111640


Homo sapiens

Features
Gene ID: ENSG00000111640
  
Biological name :GAPDH
  
Synonyms : GAPDH / glyceraldehyde-3-phosphate dehydrogenase / P04406
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 6533927
Gene end: 6538374
  
Corresponding Affymetrix probe sets: 212581_x_at (Human Genome U133 Plus 2.0 Array)   213453_x_at (Human Genome U133 Plus 2.0 Array)   217398_x_at (Human Genome U133 Plus 2.0 Array)   AFFX-HUMGAPDH/M33197_3_at (Human Genome U133 Plus 2.0 Array)   AFFX-HUMGAPDH/M33197_5_at (Human Genome U133 Plus 2.0 Array)   AFFX-HUMGAPDH/M33197_M_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380070
Ensembl peptide - ENSP00000380068
Ensembl peptide - ENSP00000478864
Ensembl peptide - ENSP00000229239
Ensembl peptide - ENSP00000380065
Ensembl peptide - ENSP00000380067
NCBI entrez gene - 2597     See in Manteia.
OMIM - 138400
RefSeq - NM_001256799
RefSeq - NM_001289745
RefSeq - NM_001289746
RefSeq - NM_002046
RefSeq Peptide - NP_001276675
RefSeq Peptide - NP_001243728
RefSeq Peptide - NP_001276674
RefSeq Peptide - NP_002037
swissprot - E7EUT5
swissprot - P04406
swissprot - V9HVZ4
Ensembl - ENSG00000111640
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gapdhENSDARG00000043457Danio rerio
 GAPDHENSGALG00000014442Gallus gallus
 Gm15294ENSMUSG00000081607Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GAPDHS / O14556 / glyceraldehyde-3-phosphate dehydrogenase, spermatogenicENSG0000010567968


Protein motifs (from Interpro)
Interpro ID Name
 IPR006424  Glyceraldehyde-3-phosphate dehydrogenase, type I
 IPR020828  Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
 IPR020829  Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
 IPR020830  Glyceraldehyde 3-phosphate dehydrogenase, active site
 IPR020831  Glyceraldehyde/Erythrose phosphate dehydrogenase family
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISS
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006094 gluconeogenesis TAS
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IDA
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0017148 negative regulation of translation IMP
 biological_processGO:0031640 killing of cells of other organism IDA
 biological_processGO:0035606 peptidyl-cysteine S-trans-nitrosylation ISS
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0050832 defense response to fungus IDA
 biological_processGO:0051402 neuron apoptotic process ISS
 biological_processGO:0051873 killing by host of symbiont cells IDA
 biological_processGO:0052501 positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061621 canonical glycolysis TAS
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097452 GAIT complex IDA
 molecular_functionGO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019828 aspartic-type endopeptidase inhibitor activity IDA
 molecular_functionGO:0035605 peptidyl-cysteine S-nitrosylase activity ISS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
Glycolysis
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111640 GAPDH / P04406 / glyceraldehyde-3-phosphate dehydrogenase  / complex






 

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