ENSG00000112378


Homo sapiens

Features
Gene ID: ENSG00000112378
  
Biological name :PERP
  
Synonyms : PERP / PERP, TP53 apoptosis effector / Q96FX8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q23.3
Gene start: 138088505
Gene end: 138107511
  
Corresponding Affymetrix probe sets: 1556990_at (Human Genome U133 Plus 2.0 Array)   217744_s_at (Human Genome U133 Plus 2.0 Array)   222392_x_at (Human Genome U133 Plus 2.0 Array)   236009_at (Human Genome U133 Plus 2.0 Array)   240797_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397157
NCBI entrez gene - 64065     See in Manteia.
OMIM - 609301
RefSeq - NM_022121
RefSeq Peptide - NP_071404
swissprot - Q96FX8
Ensembl - ENSG00000112378
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 perpENSDARG00000063572Danio rerio
 PERP1ENSGALG00000027536Gallus gallus
 PERP2ENSGALG00000027207Gallus gallus
 PerpENSMUSG00000019851Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BQJ4 / TMEM47 / transmembrane protein 47ENSG0000014702728


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR015664  P53-induced protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002934 desmosome organization IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0034113 heterotypic cell-cell adhesion IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0045862 positive regulation of proteolysis IDA
 biological_processGO:0070268 cornification TAS
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:0097186 amelogenesis IEA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA


Pathways (from Reactome)
Pathway description
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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