ENSMUSG00000019851


Mus musculus

Features
Gene ID: ENSMUSG00000019851
  
Biological name :Perp
  
Synonyms : p53 apoptosis effector related to PMP-22 / Perp / Q9JK95
  
Possible biological names infered from orthology : PERP, TP53 apoptosis effector / Q96FX8
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A3
Gene start: 18845020
Gene end: 18857073
  
Corresponding Affymetrix probe sets: 10361887 (MoGene1.0st)   1416271_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019998
NCBI entrez gene - 64058     See in Manteia.
MGI - MGI:1929938
RefSeq - NM_022032
RefSeq Peptide - NP_071315
swissprot - Q9JK95
Ensembl - ENSMUSG00000019851
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 perpENSDARG00000063572Danio rerio
 PERP1ENSGALG00000027536Gallus gallus
 PERP2ENSGALG00000027207Gallus gallus
 PERPENSG00000112378Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JJG6 / Tmem47 / Transmembrane protein 47 / Q9BQJ4*ENSMUSG0000002566627


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR015664  P53-induced protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002934 desmosome organization IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA
 biological_processGO:0097186 amelogenesis IMP
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030057 desmosome IEA


Pathways (from Reactome)
Pathway description
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pnpt1tm1.1Teit/Pnpt1tm1.1Teit
Genetic Background: involves: C57BL/6

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009581 decreased keratinocyte apoptosis "reduction in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pnpt1tm1.1Teit/Pnpt1tm1.1Teit
Genetic Background: involves: C57BL/6

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pnpt1tm1.1Teit/Pnpt1tm1.1Teit
Genetic Background: involves: C57BL/6

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pnpt1tm1.1Teit/Pnpt1tm1.1Teit
Genetic Background: involves: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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