ENSG00000115484


Homo sapiens

Features
Gene ID: ENSG00000115484
  
Biological name :CCT4
  
Synonyms : CCT4 / chaperonin containing TCP1 subunit 4 / P50991
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p15
Gene start: 61868089
Gene end: 61888804
  
Corresponding Affymetrix probe sets: 200877_at (Human Genome U133 Plus 2.0 Array)   227171_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377958
Ensembl peptide - ENSP00000443061
NCBI entrez gene - 10575     See in Manteia.
OMIM - 605142
RefSeq - NM_001256721
RefSeq - NM_006430
RefSeq Peptide - NP_001243650
RefSeq Peptide - NP_006421
swissprot - P50991
Ensembl - ENSG00000115484
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cct4ENSDARG00000013475Danio rerio
 CCT4ENSGALG00000008812Gallus gallus
 Cct4ENSMUSG00000007739Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002194  Chaperonin TCP-1, conserved site
 IPR002423  Chaperonin Cpn60/TCP-1 family
 IPR012717  T-complex protein 1, delta subunit
 IPR017998  Chaperone tailless complex polypeptide 1 (TCP-1)
 IPR027409  GroEL-like apical domain superfamily
 IPR027410  TCP-1-like chaperonin intermediate domain superfamily
 IPR027413  GroEL-like equatorial domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006458 "de novo" protein folding IBA
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0090666 scaRNA localization to Cajal body IMP
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1904851 positive regulation of establishment of protein localization to telomere IMP
 biological_processGO:1904871 positive regulation of protein localization to Cajal body IMP
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body IMP
 cellular_componentGO:0002199 zona pellucida receptor complex IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005832 chaperonin-containing T-complex TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0044183 protein binding involved in protein folding IBA
 molecular_functionGO:0051082 unfolded protein binding IBA


Pathways (from Reactome)
Pathway description
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Folding of actin by CCT/TriC
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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