ENSG00000116661


Homo sapiens

Features
Gene ID: ENSG00000116661
  
Biological name :FBXO2
  
Synonyms : F-box protein 2 / FBXO2 / Q9UK22
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.22
Gene start: 11637018
Gene end: 11655785
  
Corresponding Affymetrix probe sets: 219305_x_at (Human Genome U133 Plus 2.0 Array)   228036_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000346240
Ensembl peptide - ENSP00000493057
Ensembl peptide - ENSP00000473649
NCBI entrez gene - 26232     See in Manteia.
OMIM - 607112
RefSeq - NM_012168
RefSeq Peptide - NP_036300
swissprot - A0A286YF37
swissprot - Q9UK22
swissprot - R4GNH2
Ensembl - ENSG00000116661
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:175088ENSDARG00000099306Danio rerio
 FBXO2ENSGALG00000004657Gallus gallus
 Fbxo2ENSMUSG00000041556Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FBXO6 / Q9NRD1 / F-box protein 6ENSG0000011666343
FBXO27 / Q8NI29 / F-box protein 27ENSG0000016124337
FBXO17 / Q96EF6 / F-box protein 17ENSG0000026919034
NCCRP1 / Q6ZVX7 / non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)ENSG0000018850527
FBXO44 / Q9H4M3 / F-box protein 44ENSG0000013287923


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR007397  F-box associated (FBA) domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006516 glycoprotein catabolic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016567 protein ubiquitination ISS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0031396 regulation of protein ubiquitination IEA
 biological_processGO:0043687 post-translational protein modification TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity EXP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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