ENSMUSG00000041556


Mus musculus

Features
Gene ID: ENSMUSG00000041556
  
Biological name :Fbxo2
  
Synonyms : F-box only protein 2 / Fbxo2 / Q80UW2
  
Possible biological names infered from orthology : F-box protein 2 / Q9UK22
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 148160621
Gene end: 148166424
  
Corresponding Affymetrix probe sets: 10510299 (MoGene1.0st)   1427004_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037377
NCBI entrez gene - 230904     See in Manteia.
MGI - MGI:2446216
RefSeq - XM_006538814
RefSeq - NM_176848
RefSeq Peptide - NP_789818
swissprot - Q3USR5
swissprot - Q80UW2
Ensembl - ENSMUSG00000041556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:175088ENSDARG00000099306Danio rerio
 FBXO2ENSGALG00000004657Gallus gallus
 FBXO2ENSG00000116661Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbxo44 / F-box protein 44 / Q9H4M3*ENSMUSG0000002900142
Fbxo6 / Q9QZN4 / F-box only protein 6 / Q9NRD1* / F-box protein 6*ENSMUSG0000005540141
Fbxo27 / Q6DIA9 / Mus musculus F-box protein 27 (Fbxo27), transcript variant 3, mRNA. / Q8NI29* / F-box protein 27*ENSMUSG0000003746335
Fbxo17 / Q9QZM8 / F-box only protein 17 / Q96EF6* / F-box protein 17*ENSMUSG0000003059832
Nccrp1 / non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) / Q6ZVX7*ENSMUSG0000004758624


Protein motifs (from Interpro)
Interpro ID Name
 IPR001810  F-box domain
 IPR007397  F-box associated (FBA) domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR036047  F-box-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006516 glycoprotein catabolic process IDA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IDA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IDA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0001540 amyloid-beta binding IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IDA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000032 cochlear degeneration "a retrogressive impairment of function or destruction of the part of the inner ear forms the anterior part of the labyrinth, is conical, and is concerned with hearing" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0004300 abnormal supporting cell morphology "any structural abnormality in the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0004430 abnormal Claudius cell morphology "any structural abnormality in the columnar cells located on the floor of the ductus cochlearis external to the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0004465 degeneration of supporting cells "degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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