ENSG00000116996


Homo sapiens

Features
Gene ID: ENSG00000116996
  
Biological name :ZP4
  
Synonyms : Q12836 / zona pellucida glycoprotein 4 / ZP4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q43
Gene start: 237877864
Gene end: 237890922
  
Corresponding Affymetrix probe sets: 231756_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482304
Ensembl peptide - ENSP00000355529
NCBI entrez gene - 57829     See in Manteia.
OMIM - 613514
RefSeq - NM_021186
RefSeq Peptide - NP_067009
swissprot - Q12836
Ensembl - ENSG00000116996
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:zfos-1505d6.3ENSDARG00000089966Danio rerio
 zp2.1ENSDARG00000086352Danio rerio
 zp2.2ENSDARG00000105346Danio rerio
 zp2.3ENSDARG00000090237Danio rerio
 zp2.5ENSDARG00000086522Danio rerio
 zp2.6ENSDARG00000091409Danio rerio
 zp2l1ENSDARG00000055415Danio rerio
 zp2l2ENSDARG00000004898Danio rerio
 ZP4ENSGALG00000005462Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ZP1 / P60852 / zona pellucida glycoprotein 1ENSG0000014950637
ZP2 / Q05996 / zona pellucida glycoprotein 2ENSG0000010331029


Protein motifs (from Interpro)
Interpro ID Name
 IPR000519  P-type trefoil domain
 IPR001507  Zona pellucida domain
 IPR017957  P-type trefoil, conserved site
 IPR017977  Zona pellucida domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002922 positive regulation of humoral immune response IDA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007339 binding of sperm to zona pellucida TAS
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0060478 acrosomal vesicle exocytosis IMP
 biological_processGO:2000344 positive regulation of acrosome reaction IDA
 biological_processGO:2000360 negative regulation of binding of sperm to zona pellucida IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032190 acrosin binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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