ENSG00000149506


Homo sapiens

Features
Gene ID: ENSG00000149506
  
Biological name :ZP1
  
Synonyms : P60852 / zona pellucida glycoprotein 1 / ZP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.2
Gene start: 60867562
Gene end: 60875693
  
Corresponding Affymetrix probe sets: 237335_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000278853
Ensembl peptide - ENSP00000441293
NCBI entrez gene - 22917     See in Manteia.
OMIM - 195000
RefSeq - XM_011544853
RefSeq - NM_207341
RefSeq - XM_011544852
RefSeq Peptide - NP_997224
swissprot - P60852
swissprot - V9HWI9
swissprot - H0YG11
Ensembl - ENSG00000149506
  
Related genetic diseases (OMIM): 615774 - Oocyte maturation defect 1, 615774
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:zfos-1505d6.3ENSDARG00000089966Danio rerio
 zp2.1ENSDARG00000086352Danio rerio
 zp2.2ENSDARG00000105346Danio rerio
 zp2.3ENSDARG00000090237Danio rerio
 zp2.5ENSDARG00000086522Danio rerio
 zp2.6ENSDARG00000091409Danio rerio
 zp2l1ENSDARG00000055415Danio rerio
 zp2l2ENSDARG00000004898Danio rerio
 Zp1ENSMUSG00000024734Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ZP4 / Q12836 / zona pellucida glycoprotein 4ENSG0000011699631
ZP2 / Q05996 / zona pellucida glycoprotein 2ENSG0000010331020


Protein motifs (from Interpro)
Interpro ID Name
 IPR000519  P-type trefoil domain
 IPR001507  Zona pellucida domain
 IPR017957  P-type trefoil, conserved site
 IPR017977  Zona pellucida domain, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007339 binding of sperm to zona pellucida TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000789 Infertility 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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