ENSG00000117592


Homo sapiens

Features
Gene ID: ENSG00000117592
  
Biological name :PRDX6
  
Synonyms : P30041 / peroxiredoxin 6 / PRDX6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.1
Gene start: 173477266
Gene end: 173488807
  
Corresponding Affymetrix probe sets: 200844_s_at (Human Genome U133 Plus 2.0 Array)   200845_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342026
NCBI entrez gene - 9588     See in Manteia.
OMIM - 602316
RefSeq - NM_004905
RefSeq Peptide - NP_004896
swissprot - P30041
swissprot - V9HWC7
Ensembl - ENSG00000117592
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx6ENSDARG00000043511Danio rerio
 PRDX6ENSGALG00000003053Gallus gallus
 Prdx6ENSMUSG00000026701Mus musculus
 Prdx6bENSMUSG00000050114Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0046475 glycerophospholipid catabolic process IMP
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IMP
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0047499 calcium-independent phospholipase A2 activity IMP
 molecular_functionGO:0051920 peroxiredoxin activity IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000084207 GSTP1 / P09211 / glutathione S-transferase pi 1  / complex






 

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