ENSG00000084207


Homo sapiens

Features
Gene ID: ENSG00000084207
  
Biological name :GSTP1
  
Synonyms : glutathione S-transferase pi 1 / GSTP1 / P09211
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 67583595
Gene end: 67586656
  
Corresponding Affymetrix probe sets: 200824_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000493538
Ensembl peptide - ENSP00000381607
Ensembl peptide - ENSP00000494477
Ensembl peptide - ENSP00000484686
Ensembl peptide - ENSP00000484929
Ensembl peptide - ENSP00000381604
NCBI entrez gene - 2950     See in Manteia.
OMIM - 134660
RefSeq - NM_000852
RefSeq Peptide - NP_000843
swissprot - A0A087X2E9
swissprot - A0A087X243
swissprot - A8MX94
swissprot - P09211
swissprot - V9HWE9
Ensembl - ENSG00000084207
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gstp1ENSDARG00000104068Danio rerio
 gstp2ENSDARG00000103019Danio rerio
 Gstp1ENSMUSG00000060803Mus musculus
 Gstp2ENSMUSG00000038155Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSTM3 / P21266 / glutathione S-transferase mu 3ENSG0000013420232
GSTM2 / P28161 / glutathione S-transferase mu 2ENSG0000021336630
GSTM5 / P46439 / glutathione S-transferase mu 5ENSG0000013420129
GSTM4 / Q03013 / glutathione S-transferase mu 4ENSG0000016876528
GSTM1 / P09488 / glutathione S-transferase mu 1ENSG0000013418428


Protein motifs (from Interpro)
Interpro ID Name
 IPR003082  Glutathione S-transferase, Pi class
 IPR004045  Glutathione S-transferase, N-terminal
 IPR004046  Glutathione S-transferase, C-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species ISS
 biological_processGO:0002674 negative regulation of acute inflammatory response NAS
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006749 glutathione metabolic process IDA
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009890 negative regulation of biosynthetic process IDA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IC
 biological_processGO:0014003 oligodendrocyte development IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IDA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032872 regulation of stress-activated MAPK cascade ISS
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade ISS
 biological_processGO:0032930 positive regulation of superoxide anion generation ISS
 biological_processGO:0033591 response to L-ascorbic acid IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0035726 common myeloid progenitor cell proliferation ISS
 biological_processGO:0035732 nitric oxide storage NAS
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043407 negative regulation of MAP kinase activity IDA
 biological_processGO:0043409 negative regulation of MAPK cascade NAS
 biological_processGO:0043508 negative regulation of JUN kinase activity IDA
 biological_processGO:0043651 linoleic acid metabolic process IDA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation ISS
 biological_processGO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070664 negative regulation of leukocyte proliferation ISS
 biological_processGO:0071222 cellular response to lipopolysaccharide ISS
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0071460 cellular response to cell-matrix adhesion IEA
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IDA
 biological_processGO:0071672 negative regulation of smooth muscle cell chemotaxis IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1901687 glutathione derivative biosynthetic process TAS
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097057 TRAF2-GSTP1 complex IDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0004364 glutathione transferase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008432 JUN kinase binding ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019207 kinase regulator activity ISS
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0035730 S-nitrosoglutathione binding IDA
 molecular_functionGO:0035731 dinitrosyl-iron complex binding IDA
 molecular_functionGO:0043295 glutathione binding IEA
 molecular_functionGO:0070026 nitric oxide binding NAS


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Detoxification of Reactive Oxygen Species
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117592 PRDX6 / P30041 / peroxiredoxin 6  / complex
 ENSG00000084207 GSTP1 / P09211 / glutathione S-transferase pi 1  / complex






 

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