ENSG00000213366


Homo sapiens

Features
Gene ID: ENSG00000213366
  
Biological name :GSTM2
  
Synonyms : glutathione S-transferase mu 2 / GSTM2 / P28161
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.3
Gene start: 109668022
Gene end: 109709551
  
Corresponding Affymetrix probe sets: 204418_x_at (Human Genome U133 Plus 2.0 Array)   204550_x_at (Human Genome U133 Plus 2.0 Array)   215333_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358844
Ensembl peptide - ENSP00000358846
Ensembl peptide - ENSP00000435910
Ensembl peptide - ENSP00000435157
Ensembl peptide - ENSP00000416883
Ensembl peptide - ENSP00000404662
Ensembl peptide - ENSP00000241337
Ensembl peptide - ENSP00000358842
NCBI entrez gene - 2946     See in Manteia.
OMIM - 138380
RefSeq - NM_001142368
RefSeq - NM_000848
RefSeq Peptide - NP_000839
RefSeq Peptide - NP_001135840
swissprot - F6XZQ7
swissprot - E9PLF1
swissprot - P28161
swissprot - E9PHN7
swissprot - E9PHN6
swissprot - E9PGV1
Ensembl - ENSG00000213366
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gstm.1ENSDARG00000042533Danio rerio
 gstm.2ENSDARG00000029473Danio rerio
 gstm.3ENSDARG00000088116Danio rerio
 GSTM2ENSGALG00000032922Gallus gallus
 Gstm7ENSMUSG00000004035Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GSTM1 / P09488 / glutathione S-transferase mu 1ENSG0000013418484
GSTM4 / Q03013 / glutathione S-transferase mu 4ENSG0000016876583
GSTM5 / P46439 / glutathione S-transferase mu 5ENSG0000013420181
GSTM3 / P21266 / glutathione S-transferase mu 3ENSG0000013420268
GSTP1 / P09211 / glutathione S-transferase pi 1ENSG0000008420728


Protein motifs (from Interpro)
Interpro ID Name
 IPR003081  Glutathione S-transferase, Mu class
 IPR004045  Glutathione S-transferase, N-terminal
 IPR004046  Glutathione S-transferase, C-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006749 glutathione metabolic process IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
 biological_processGO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC
 biological_processGO:0018916 nitrobenzene metabolic process IDA
 biological_processGO:0042178 xenobiotic catabolic process IDA
 biological_processGO:0043651 linoleic acid metabolic process IDA
 biological_processGO:0055119 relaxation of cardiac muscle TAS
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity IDA
 biological_processGO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity IDA
 biological_processGO:0070458 cellular detoxification of nitrogen compound IDA
 biological_processGO:0071313 cellular response to caffeine IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1901687 glutathione derivative biosynthetic process TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004364 glutathione transferase activity IEA
 molecular_functionGO:0004602 glutathione peroxidase activity IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043295 glutathione binding IDA


Pathways (from Reactome)
Pathway description
Glutathione conjugation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000213366 GSTM2 / P28161 / glutathione S-transferase mu 2  / complex






 

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