ENSMUSG00000060803


Mus musculus

Features
Gene ID: ENSMUSG00000060803
  
Biological name :Gstp1
  
Synonyms : Glutathione S-transferase P 1 / Gstp1 / P19157
  
Possible biological names infered from orthology : glutathione S-transferase pi 1 / P09211
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4035407
Gene end: 4037921
  
Corresponding Affymetrix probe sets: 10361152 (MoGene1.0st)   10464583 (MoGene1.0st)   10464586 (MoGene1.0st)   1449575_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129565
NCBI entrez gene - 14870     See in Manteia.
MGI - MGI:95865
RefSeq - NM_013541
RefSeq Peptide - NP_038569
swissprot - P19157
Ensembl - ENSMUSG00000060803
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gstp1ENSDARG00000104068Danio rerio
 gstp2ENSDARG00000103019Danio rerio
 GSTP1ENSG00000084207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gstp2 / P46425 / Glutathione S-transferase P 2 / GSTP1* / P09211* / glutathione S-transferase pi 1*ENSMUSG0000003815597
Gstp3ENSMUSG0000005821670
Gstm5 / P48774 / Glutathione S-transferase Mu 5 / GSTM3* / P21266* / glutathione S-transferase mu 3*ENSMUSG0000000403232
Gstm7 / Q80W21 / Glutathione S-transferase Mu 7 / GSTM2* / P28161* / glutathione S-transferase mu 2*ENSMUSG0000000403531
Gstm1 / P10649 / Glutathione S-transferase Mu 1 ENSMUSG0000005813531
Gstm6 / O35660 / Glutathione S-transferase Mu 6 / GSTM5* / GSTM1* / P09488* / P46439* / glutathione S-transferase mu 5* / glutathione S-transferase mu 1*ENSMUSG0000006876231
Gstm4 / glutathione S-transferase mu 4 / Q03013*ENSMUSG0000002789030
Gstm3 / P19639 / Glutathione S-transferase Mu 3 ENSMUSG0000000403829
Gstm2 / P15626 / Glutathione S-transferase Mu 2 / GSTM5* / GSTM1* / P09488* / P46439* / glutathione S-transferase mu 1* / glutathione S-transferase mu 5*ENSMUSG0000004056228
Gm6665 / GSTM1* / GSTM5* / P46439* / P09488* / glutathione S-transferase mu 1* / glutathione S-transferase mu 5*ENSMUSG0000009156111


Protein motifs (from Interpro)
Interpro ID Name
 IPR003082  Glutathione S-transferase, Pi class
 IPR004045  Glutathione S-transferase, N-terminal
 IPR004046  Glutathione S-transferase, C-terminal
 IPR010987  Glutathione S-transferase, C-terminal-like
 IPR036249  Thioredoxin-like superfamily
 IPR036282  Glutathione S-transferase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000302 response to reactive oxygen species IDA
 biological_processGO:0002674 negative regulation of acute inflammatory response NAS
 biological_processGO:0006749 glutathione metabolic process IDA
 biological_processGO:0006805 xenobiotic metabolic process ISS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009636 response to toxic substance ISS
 biological_processGO:0014003 oligodendrocyte development ISS
 biological_processGO:0031100 animal organ regeneration ISS
 biological_processGO:0031667 response to nutrient levels ISS
 biological_processGO:0032355 response to estradiol ISS
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IDA
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0032872 regulation of stress-activated MAPK cascade IDA
 biological_processGO:0032873 negative regulation of stress-activated MAPK cascade IDA
 biological_processGO:0032930 positive regulation of superoxide anion generation IMP
 biological_processGO:0033591 response to L-ascorbic acid ISS
 biological_processGO:0035726 common myeloid progenitor cell proliferation IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043200 response to amino acid ISS
 biological_processGO:0043407 negative regulation of MAP kinase activity ISS
 biological_processGO:0043508 negative regulation of JUN kinase activity IMP
 biological_processGO:0045471 response to ethanol ISS
 biological_processGO:0048147 negative regulation of fibroblast proliferation IMP
 biological_processGO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IDA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070664 negative regulation of leukocyte proliferation IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus ISS
 biological_processGO:0071385 cellular response to glucocorticoid stimulus ISS
 biological_processGO:0071460 cellular response to cell-matrix adhesion ISS
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production IDA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2000429 negative regulation of neutrophil aggregation NAS
 biological_processGO:2000469 negative regulation of peroxidase activity IDA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0097057 TRAF2-GSTP1 complex ISO
 molecular_functionGO:0004364 glutathione transferase activity ISO
 molecular_functionGO:0004602 glutathione peroxidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding ISS
 molecular_functionGO:0008432 JUN kinase binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019207 kinase regulator activity IMP
 molecular_functionGO:0035730 S-nitrosoglutathione binding ISO
 molecular_functionGO:0035731 dinitrosyl-iron complex binding ISO


Pathways (from Reactome)
Pathway description
Glutathione conjugation
Detoxification of Reactive Oxygen Species
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Tbx15de/Tbx15de
Genetic Background: STOCK J

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbx15de/Tbx15de
Genetic Background: STOCK J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026701 Prdx6 / peroxiredoxin 6 / P30041*  / complex
 ENSMUSG00000050114 Prdx6b / peroxiredoxin 6B / PRDX6* / P30041* / peroxiredoxin 6*  / complex
 ENSMUSG00000038155 Gstp2 / P46425 / Glutathione S-transferase P 2 / GSTP1* / P09211* / glutathione S-transferase pi 1*  / complex
 ENSMUSG00000060803 Gstp1 / P19157 / Glutathione S-transferase P 1 / P09211* / glutathione S-transferase pi 1*  / complex






 

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