ENSMUSG00000026701


Mus musculus

Features
Gene ID: ENSMUSG00000026701
  
Biological name :Prdx6
  
Synonyms : peroxiredoxin 6 / Prdx6
  
Possible biological names infered from orthology : P30041
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H2.1
Gene start: 161240112
Gene end: 161251219
  
Corresponding Affymetrix probe sets: 10359422 (MoGene1.0st)   1423223_a_at (Mouse Genome 430 2.0 Array)   1442878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071636
Ensembl peptide - ENSMUSP00000142093
Ensembl peptide - ENSMUSP00000050703
NCBI entrez gene - 11758     See in Manteia.
MGI - MGI:894320
RefSeq - NM_007453
RefSeq - NM_001303408
RefSeq Peptide - NP_001290337
RefSeq Peptide - NP_031479
swissprot - Q6GT24
swissprot - D3Z0Y2
swissprot - A0A0A6YXQ7
Ensembl - ENSMUSG00000026701
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prdx6ENSDARG00000043511Danio rerio
 PRDX6ENSGALG00000003053Gallus gallus
 PRDX6ENSG00000117592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prdx6b / peroxiredoxin 6B / PRDX6* / P30041* / peroxiredoxin 6*ENSMUSG0000005011486


Protein motifs (from Interpro)
Interpro ID Name
 IPR000866  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
 IPR013766  Thioredoxin domain
 IPR019479  Peroxiredoxin, C-terminal
 IPR024706  Peroxiredoxin, AhpC-type
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0051920 peroxiredoxin activity IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Prdx6tm1a(EUCOMM)Wtsi/Prdx6tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002271 abnormal alveolar duct morphology "any structural anomaly of the conducting tubes leading to the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smcr8tm1.1(KOMP)Vlcg/Smcr8tm1.1(KOMP)Vlcg
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smcr8tm1.1(KOMP)Vlcg/Smcr8tm1.1(KOMP)Vlcg
Genetic Background: involves: 129S1/SvImJ * C57BL/6J * C57BL/6NTac

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010857 pulmonary necrosis "pathological cell death in the lung, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010858 pulmonary epithelial necrosis "pathological cell death in the lung epithelium, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010894 pulmonary alveolar edema "an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Pgrtm2Omc/Pgrtm2Omc
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038155 Gstp2 / P46425 / Glutathione S-transferase P 2 / GSTP1* / P09211* / glutathione S-transferase pi 1*  / complex
 ENSMUSG00000060803 Gstp1 / P19157 / Glutathione S-transferase P 1 / P09211* / glutathione S-transferase pi 1*  / complex






 

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