ENSG00000119927


Homo sapiens

Features
Gene ID: ENSG00000119927
  
Biological name :GPAM
  
Synonyms : glycerol-3-phosphate acyltransferase, mitochondrial / GPAM / Q9HCL2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q25.2
Gene start: 112149864
Gene end: 112215377
  
Corresponding Affymetrix probe sets: 225420_at (Human Genome U133 Plus 2.0 Array)   225424_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265276
Ensembl peptide - ENSP00000358433
NCBI entrez gene - 57678     See in Manteia.
OMIM - 602395
RefSeq - XM_005269998
RefSeq - NM_001244949
RefSeq - NM_020918
RefSeq Peptide - NP_065969
RefSeq Peptide - NP_001231878
swissprot - Q5VW52
swissprot - Q9HCL2
Ensembl - ENSG00000119927
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpamENSDARG00000074169Danio rerio
 GPAMENSGALG00000008795Gallus gallus
 GpamENSMUSG00000024978Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPAT2 / Q6NUI2 / glycerol-3-phosphate acyltransferase 2, mitochondrialENSG0000018628129
GNPAT / O15228 / glyceronephosphate O-acyltransferaseENSG0000011690618


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR022284  Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
 IPR028354  Glycerol-3-phosphate acyltransferase, PlsB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006637 acyl-CoA metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006650 glycerophospholipid metabolic process IEA
 biological_processGO:0006654 phosphatidic acid biosynthetic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 biological_processGO:0019432 triglyceride biosynthetic process TAS
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway TAS
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0044255 cellular lipid metabolic process IEA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0055089 fatty acid homeostasis IEA
 biological_processGO:0055091 phospholipid homeostasis IEA
 biological_processGO:0070236 negative regulation of activation-induced cell death of T cells IEA
 biological_processGO:0070970 interleukin-2 secretion IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0004366 glycerol-3-phosphate O-acyltransferase activity IEA
 molecular_functionGO:0008374 O-acyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0102420 sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Activation of gene expression by SREBF (SREBP)
Triglyceride biosynthesis
RUNX1 regulates estrogen receptor mediated transcription
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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