ENSMUSG00000024978


Mus musculus

Features
Gene ID: ENSMUSG00000024978
  
Biological name :Gpam
  
Synonyms : glycerol-3-phosphate acyltransferase, mitochondrial / Gpam / Q61586
  
Possible biological names infered from orthology : Q9HCL2
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: D2
Gene start: 55069734
Gene end: 55099451
  
Corresponding Affymetrix probe sets: 10468533 (MoGene1.0st)   1419499_at (Mouse Genome 430 2.0 Array)   1425834_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057635
NCBI entrez gene - 14732     See in Manteia.
MGI - MGI:109162
RefSeq - XM_011247147
RefSeq - NM_008149
RefSeq - XM_006526692
RefSeq - XM_006526693
RefSeq - XM_006526694
RefSeq Peptide - NP_032175
RefSeq Peptide - NP_001343214
swissprot - Q61586
Ensembl - ENSMUSG00000024978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpamENSDARG00000074169Danio rerio
 GPAMENSGALG00000008795Gallus gallus
 GPAMENSG00000119927Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpat2 / Q14DK4 / glycerol-3-phosphate acyltransferase 2, mitochondrial / Q6NUI2*ENSMUSG0000004633830
Gnpat / P98192 / glyceronephosphate O-acyltransferase / O15228*ENSMUSG0000003198518


Protein motifs (from Interpro)
Interpro ID Name
 IPR002123  Phospholipid/glycerol acyltransferase
 IPR022284  Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
 IPR028354  Glycerol-3-phosphate acyltransferase, PlsB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IMP
 biological_processGO:0006637 acyl-CoA metabolic process IMP
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006650 glycerophospholipid metabolic process IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0016024 CDP-diacylglycerol biosynthetic process IEA
 biological_processGO:0019432 triglyceride biosynthetic process IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042104 positive regulation of activated T cell proliferation IMP
 biological_processGO:0044255 cellular lipid metabolic process IEA
 biological_processGO:0050707 regulation of cytokine secretion IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0055089 fatty acid homeostasis IMP
 biological_processGO:0055091 phospholipid homeostasis IMP
 biological_processGO:0070236 negative regulation of activation-induced cell death of T cells IMP
 biological_processGO:0070970 interleukin-2 secretion IMP
 cellular_componentGO:0005739 mitochondrion IMP
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004366 glycerol-3-phosphate O-acyltransferase activity ISO
 molecular_functionGO:0008374 O-acyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0102420 sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA
Triglyceride biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Foxp2S321X/Foxp2S321X
Genetic Background: involves: C3HeB/FeJ

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0003976 decreased circulating VLDL triglyceride level "lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gpamtm1Lex/Gpamtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009305 decreased retroperitoneal fat pad weight 
Show

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptstm1Ich/Ptstm1Ich
Genetic Background: B6.129X1-Ptstm1Ich

Allelic Composition: Gpamtm1.1Dali/Gpamtm1.1Dali
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr