ENSG00000120915


Homo sapiens

Features
Gene ID: ENSG00000120915
  
Biological name :EPHX2
  
Synonyms : EPHX2 / epoxide hydrolase 2 / P34913
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.2
Gene start: 27490779
Gene end: 27545564
  
Corresponding Affymetrix probe sets: 209368_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428191
Ensembl peptide - ENSP00000428875
Ensembl peptide - ENSP00000430779
Ensembl peptide - ENSP00000430302
Ensembl peptide - ENSP00000430269
Ensembl peptide - ENSP00000369843
Ensembl peptide - ENSP00000427956
NCBI entrez gene - 2053     See in Manteia.
OMIM - 132811
RefSeq - XM_017013199
RefSeq - NM_001256482
RefSeq - NM_001256483
RefSeq - NM_001256484
RefSeq - NM_001979
RefSeq Peptide - NP_001243413
RefSeq Peptide - NP_001243411
RefSeq Peptide - NP_001243412
RefSeq Peptide - NP_001970
swissprot - H0YAW7
swissprot - E5RFU2
swissprot - P34913
swissprot - E5RI53
swissprot - E5RFH6
Ensembl - ENSG00000120915
  
Related genetic diseases (OMIM): 143890 - {Hypercholesterolemia, familial, due to LDLR defect, modifier of}, 143890
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephx2ENSDARG00000040255Danio rerio
 EPHX2ENSGALG00000016567Gallus gallus
 Ephx2ENSMUSG00000022040Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPHX4 / Q8IUS5 / epoxide hydrolase 4ENSG0000017203118
EPHX3 / Q9H6B9 / epoxide hydrolase 3ENSG0000010513116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000073  Alpha/beta hydrolase fold-1
 IPR000639  Epoxide hydrolase-like
 IPR006439  HAD hydrolase, subfamily IA
 IPR011945  Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal
 IPR023198  Phosphoglycolate phosphatase-like, domain 2
 IPR023214  HAD superfamily
 IPR029058  Alpha/Beta hydrolase fold
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process NAS
 biological_processGO:0006874 cellular calcium ion homeostasis NAS
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008217 regulation of blood pressure NAS
 biological_processGO:0009636 response to toxic substance NAS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0017144 drug metabolic process NAS
 biological_processGO:0019373 epoxygenase P450 pathway TAS
 biological_processGO:0019439 aromatic compound catabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IDA
 biological_processGO:0046272 stilbene catabolic process IDA
 biological_processGO:0046839 phospholipid dephosphorylation IDA
 biological_processGO:0072593 reactive oxygen species metabolic process NAS
 biological_processGO:0090181 regulation of cholesterol metabolic process IMP
 biological_processGO:0097176 epoxide metabolic process IDA
 biological_processGO:0097755 positive regulation of blood vessel diameter NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004301 epoxide hydrolase activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0015643 toxic substance binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IDA
 molecular_functionGO:0033885 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity IEA
 molecular_functionGO:0042577 lipid phosphatase activity IDA
 molecular_functionGO:0042803 protein homodimerization activity NAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Biosynthesis of maresins
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120915 EPHX2 / P34913 / epoxide hydrolase 2  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr