ENSMUSG00000022040


Mus musculus

Features
Gene ID: ENSMUSG00000022040
  
Biological name :Ephx2
  
Synonyms : Bifunctional epoxide hydrolase 2 Cytosolic epoxide hydrolase 2 Lipid-phosphate phosphatase / Ephx2 / P34914
  
Possible biological names infered from orthology : epoxide hydrolase 2 / P34913
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 66084374
Gene end: 66124500
  
Corresponding Affymetrix probe sets: 10420935 (MoGene1.0st)   1448499_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069209
Ensembl peptide - ENSMUSP00000152894
Ensembl peptide - ENSMUSP00000153161
NCBI entrez gene - 13850     See in Manteia.
MGI - MGI:99500
RefSeq - NM_001271403
RefSeq - NM_001271402
RefSeq - NM_001271421
RefSeq - NM_007940
RefSeq Peptide - NP_001258331
RefSeq Peptide - NP_001258332
RefSeq Peptide - NP_001258350
RefSeq Peptide - NP_031966
swissprot - P34914
swissprot - A8JYK8
Ensembl - ENSMUSG00000022040
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephx2ENSDARG00000040255Danio rerio
 EPHX2ENSGALG00000016567Gallus gallus
 EPHX2ENSG00000120915Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ephx3 / Mus musculus epoxide hydrolase 3 (Ephx3), transcript variant 2, mRNA. / Q9H6B9* / epoxide hydrolase 3*ENSMUSG0000003757718
Ephx4 / Q6IE26 / Epoxide hydrolase 4 / Q8IUS5*ENSMUSG0000003380516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000073  Alpha/beta hydrolase fold-1
 IPR000639  Epoxide hydrolase-like
 IPR006439  HAD hydrolase, subfamily IA
 IPR023198  Phosphoglycolate phosphatase-like, domain 2
 IPR023214  HAD superfamily
 IPR029058  Alpha/Beta hydrolase fold
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0019439 aromatic compound catabolic process IEA
 biological_processGO:0042632 cholesterol homeostasis IEA
 biological_processGO:0046272 stilbene catabolic process IEA
 biological_processGO:0046839 phospholipid dephosphorylation IEA
 biological_processGO:0090181 regulation of cholesterol metabolic process IMP
 biological_processGO:0097176 epoxide metabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome ISO
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004301 epoxide hydrolase activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0015643 toxic substance binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0033885 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity IEA
 molecular_functionGO:0042577 lipid phosphatase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Biosynthesis of maresins
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: B6.129P2(FVB)-Abcc2tm1Ahs

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: B6.129P2(FVB)-Abcc2tm1Ahs

Allelic Composition: Ephx2tm1.1Arte/Ephx2tm1.1Arte,Tg(Pdgfra-cre)1Clc/0
Genetic Background: involves: C57BL/6

Allelic Composition: Ephx2tm1.1Arte/Ephx2tm1.1Arte,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: B6.129P2(FVB)-Abcc2tm1Ahs

Allelic Composition: Ephx2tm1.1Arte/Ephx2tm1.1Arte,Tg(Pdgfra-cre)1Clc/0
Genetic Background: involves: C57BL/6

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Thpotm1Mwm/Thpo+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022040 Ephx2 / P34914 / Bifunctional epoxide hydrolase 2 Cytosolic epoxide hydrolase 2 Lipid-phosphate phosphatase / P34913* / epoxide hydrolase 2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr