ENSG00000121653


Homo sapiens

Features
Gene ID: ENSG00000121653
  
Biological name :MAPK8IP1
  
Synonyms : MAPK8IP1 / mitogen-activated protein kinase 8 interacting protein 1 / Q9UQF2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 45885651
Gene end: 45906465
  
Corresponding Affymetrix probe sets: 213013_at (Human Genome U133 Plus 2.0 Array)   213014_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000241014
Ensembl peptide - ENSP00000378991
NCBI entrez gene - 9479     See in Manteia.
OMIM - 604641
RefSeq - NM_005456
RefSeq - XM_005253226
RefSeq Peptide - NP_005447
swissprot - E9PBB9
swissprot - Q9UQF2
Ensembl - ENSG00000121653
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, noninsulin-dependent}, 125853
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK8IP1 (1 of many)ENSDARG00000090326Danio rerio
 mapk8ip1aENSDARG00000102229Danio rerio
 ENSGALG00000033060Gallus gallus
 ENSGALG00000030732Gallus gallus
 Q9WVI9ENSMUSG00000027223Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13387 / MAPK8IP2 / mitogen-activated protein kinase 8 interacting protein 2ENSG0000000873538


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR035638  JIP1, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007258 JUN phosphorylation IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IEA
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0044302 dentate gyrus mossy fiber IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity TAS
 molecular_functionGO:0005078 MAP-kinase scaffold activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008432 JUN kinase binding IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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