ENSMUSG00000027223


Mus musculus

Features
Gene ID: ENSMUSG00000027223
  
Biological name :Mapk8ip1
  
Synonyms : C-Jun-amino-terminal kinase-interacting protein 1 / Mapk8ip1 / Q9WVI9
  
Possible biological names infered from orthology : mitogen-activated protein kinase 8 interacting protein 1 / Q9UQF2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E1
Gene start: 92383676
Gene end: 92401263
  
Corresponding Affymetrix probe sets: 10485151 (MoGene1.0st)   1425679_a_at (Mouse Genome 430 2.0 Array)   1440619_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050773
Ensembl peptide - ENSMUSP00000106910
NCBI entrez gene - 19099     See in Manteia.
MGI - MGI:1309464
RefSeq - XM_006498954
RefSeq - NM_001202445
RefSeq - NM_001202446
RefSeq - NM_011162
RefSeq - XM_006498953
RefSeq Peptide - NP_035292
RefSeq Peptide - NP_001189374
RefSeq Peptide - NP_001189375
swissprot - Q9WVI9
Ensembl - ENSMUSG00000027223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAPK8IP1 (1 of many)ENSDARG00000090326Danio rerio
 mapk8ip1aENSDARG00000102229Danio rerio
 ENSGALG00000033060Gallus gallus
 ENSGALG00000030732Gallus gallus
 Q9UQF2ENSG00000121653Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9ERE9 / Mapk8ip2 / C-Jun-amino-terminal kinase-interacting protein 2 / Q13387* / mitogen-activated protein kinase 8 interacting protein 2*ENSMUSG0000002261938


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR035638  JIP1, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007258 JUN phosphorylation IDA
 biological_processGO:0016192 vesicle-mediated transport IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IEA
 biological_processGO:0046328 regulation of JNK cascade IMP
 biological_processGO:0046329 negative regulation of JNK cascade IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0044302 dentate gyrus mossy fiber IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008432 JUN kinase binding IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ghrtm1.2Masp/Ghrtm1.2Masp
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002888 abnormal NMDA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cenpbtm1Khac/Cenpbtm1Khac
Genetic Background: B6.129-Cenpbtm1Khac

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Mapk7tm1Wnt/Mapk7tm1Wnt
Genetic Background: involves: C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Trip13Gt(CH0621)Wtsi/Trip13Gt(CH0621)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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