ENSMUSG00000022619


Mus musculus

Features
Gene ID: ENSMUSG00000022619
  
Biological name :Mapk8ip2
  
Synonyms : C-Jun-amino-terminal kinase-interacting protein 2 / Mapk8ip2 / Q9ERE9
  
Possible biological names infered from orthology : mitogen-activated protein kinase 8 interacting protein 2 / Q13387
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E3
Gene start: 89453913
Gene end: 89464468
  
Corresponding Affymetrix probe sets: 10426244 (MoGene1.0st)   1418785_at (Mouse Genome 430 2.0 Array)   1418786_at (Mouse Genome 430 2.0 Array)   1435045_s_at (Mouse Genome 430 2.0 Array)   1449225_a_at (Mouse Genome 430 2.0 Array)   1455194_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023291
NCBI entrez gene - 60597     See in Manteia.
MGI - MGI:1926555
RefSeq - NM_021921
RefSeq Peptide - NP_068740
swissprot - Q548W8
swissprot - Q9ERE9
Ensembl - ENSMUSG00000022619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk8ip2ENSDARG00000063157Danio rerio
 Q13387ENSG00000008735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WVI9 / Mapk8ip1 / C-Jun-amino-terminal kinase-interacting protein 1 / Q9UQF2* / mitogen-activated protein kinase 8 interacting protein 1*ENSMUSG0000002722332


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR035637  JIP2, SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0007254 JNK cascade IDA
 biological_processGO:0007617 mating behavior IMP
 biological_processGO:0010469 regulation of signaling receptor activity IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0035176 social behavior IMP
 biological_processGO:0046328 regulation of JNK cascade IEA
 biological_processGO:0046958 nonassociative learning IMP
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060079 excitatory postsynaptic potential IMP
 biological_processGO:2000310 regulation of NMDA receptor activity IMP
 biological_processGO:2000311 regulation of AMPA receptor activity IMP
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019894 kinesin binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030295 protein kinase activator activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Grhl2Gt(RRU622)Byg/Grhl2Gt(RRU622)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

 MP:0002888 abnormal NMDA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gab1tm2Wbm/Gab1tm2Wbm
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0003234 enhanced NMDA-mediated synaptic currents "increase in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0011003 reduced AMPA-mediated synaptic currents "reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk8ip2tm1.1Gol/Mapk8ip2tm1.1Gol
Genetic Background: 129S/SvEv-Mapk8ip2tm1.1Gol

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mapk8ip1tm1Rjd/Mapk8ip1tm1Rjd,Mapk8ip2tm1Rjd/Mapk8ip2tm1Rjd
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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