ENSG00000122121


Homo sapiens

Features
Gene ID: ENSG00000122121
  
Biological name :XPNPEP2
  
Synonyms : O43895 / XPNPEP2 / X-prolyl aminopeptidase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q26.1
Gene start: 129738974
Gene end: 129769538
  
Corresponding Affymetrix probe sets: 206484_s_at (Human Genome U133 Plus 2.0 Array)   216910_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360146
Ensembl peptide - ENSP00000360147
NCBI entrez gene - 7512     See in Manteia.
OMIM - 300145
RefSeq - NM_003399
RefSeq Peptide - NP_003390
swissprot - O43895
swissprot - Q5JZ40
Ensembl - ENSG00000122121
  
Related genetic diseases (OMIM): 300909 - {Angioedema induced by ACE inhibitors, susceptibility to}, 300909
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xpnpep2ENSDARG00000026017Danio rerio
 XPNPEP2ENSGALG00000025935Gallus gallus
 B1AVD1ENSMUSG00000037005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NQW7 / XPNPEP1 / X-prolyl aminopeptidase 1ENSG0000010803939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000587  Creatinase, N-terminal
 IPR000994  Peptidase M24
 IPR001131  Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site
 IPR029149  Creatinase/Aminopeptidase P/Spt16, N-terminal
 IPR032416  Peptidase M24, C-terminal domain
 IPR033740  Aminopeptidase P
 IPR036005  Creatinase/aminopeptidase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006501 C-terminal protein lipidation TAS
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0004177 aminopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122121 O43895 / XPNPEP2 / X-prolyl aminopeptidase 2  / complex






 

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