ENSG00000124217


Homo sapiens

Features
Gene ID: ENSG00000124217
  
Biological name :MOCS3
  
Synonyms : MOCS3 / molybdenum cofactor synthesis 3 / O95396
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.13
Gene start: 50958826
Gene end: 50963931
  
Corresponding Affymetrix probe sets: 206141_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000244051
NCBI entrez gene - 27304     See in Manteia.
OMIM - 609277
RefSeq - NM_014484
RefSeq Peptide - NP_055299
swissprot - O95396
Ensembl - ENSG00000124217
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mocs3ENSDARG00000008239Danio rerio
 MOCS3ENSGALG00000007986Gallus gallus
 Mocs3ENSMUSG00000074576Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR001763  Rhodanese-like domain
 IPR028885  Adenylyltransferase and sulfurtransferase MOCS3/Uba4
 IPR035985  Ubiquitin-activating enzyme
 IPR036873  Rhodanese-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002098 tRNA wobble uridine modification IDA
 biological_processGO:0002143 tRNA wobble position uridine thiolation IBA
 biological_processGO:0006777 Mo-molybdopterin cofactor biosynthetic process IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0018192 enzyme active site formation via cysteine modification to L-cysteine persulfide IDA
 biological_processGO:0032324 molybdopterin cofactor biosynthetic process TAS
 biological_processGO:0032447 protein urmylation IBA
 biological_processGO:0034227 tRNA thio-modification IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004792 thiosulfate sulfurtransferase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IDA
 molecular_functionGO:0016783 sulfurtransferase activity TAS
 molecular_functionGO:0042292 URM1 activating enzyme activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061604 molybdopterin-synthase sulfurtransferase activity IEA
 molecular_functionGO:0061605 molybdopterin-synthase adenylyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Molybdenum cofactor biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164172 MOCS2 / O96007 / O96033 / molybdenum cofactor synthesis 2  / reaction
 ENSG00000244005 NFS1 / Q9Y697 / NFS1, cysteine desulfurase  / reaction






 

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